Sodium Chloride 0.9% Intravenous Solution

Department of Medical Services Ministry of Public Health of Thailand · FDA-approved active Small molecule

Sodium Chloride 0.9% Intravenous Solution is a Electrolyte replacement solution Small molecule drug developed by Department of Medical Services Ministry of Public Health of Thailand. It is currently FDA-approved for Fluid and electrolyte replacement in dehydration, Maintenance of fluid balance during surgery or acute illness, Vehicle for intravenous medication administration. Also known as: placebo comparator, Physiologic saline.

Sodium chloride 0.9% restores and maintains electrolyte balance and fluid volume in the body by providing isotonic saline solution.

Sodium Chloride 0.9% Intravenous Solution is used in clinical trials for conditions such as postoperative pain, obesity, type 2 diabetes mellitus, acute postoperative pain, and chronic postoperative pain. The solution's mechanism of action is unknown, and it is not classified as an anticoagulant.

At a glance

Generic name	Sodium Chloride 0.9% Intravenous Solution
Also known as	placebo comparator, Physiologic saline
Sponsor	Department of Medical Services Ministry of Public Health of Thailand
Drug class	Electrolyte replacement solution
Modality	Small molecule
Therapeutic area	Fluid and electrolyte management
Phase	FDA-approved

Mechanism of action

This intravenous solution contains sodium and chloride ions in physiologic concentration (0.9% w/v), matching the osmolality of blood plasma. It is used to replace lost fluids and electrolytes, maintain hydration, and serve as a vehicle for administering other medications. The isotonic nature prevents cell lysis or crenation.

Approved indications

• Fluid and electrolyte replacement in dehydration
• Maintenance of fluid balance during surgery or acute illness
• Vehicle for intravenous medication administration
• Treatment of hypovolemia and shock

Common side effects

• Hyperchloremic acidosis
• Fluid overload
• Hypernatremia
• Phlebitis at injection site

Key clinical trials

• Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC) (PHASE2, PHASE3)
• Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies (PHASE1)
• Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
• Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial (PHASE3)
• Intravenous Lidocaine Infusion in Lumbar Fusion Surgery (NA)
• Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI) (PHASE2)
• Angiotensin II in Liver Transplantation (PHASE2, PHASE3)
• The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Sodium Chloride 0.9% Intravenous Solution CI brief — competitive landscape report
• Sodium Chloride 0.9% Intravenous Solution updates RSS · CI watch RSS
• Department of Medical Services Ministry of Public Health of Thailand portfolio CI

Frequently asked questions about Sodium Chloride 0.9% Intravenous Solution

What is Sodium Chloride 0.9% Intravenous Solution?

Sodium Chloride 0.9% Intravenous Solution is a Electrolyte replacement solution drug developed by Department of Medical Services Ministry of Public Health of Thailand, indicated for Fluid and electrolyte replacement in dehydration, Maintenance of fluid balance during surgery or acute illness, Vehicle for intravenous medication administration.

How does Sodium Chloride 0.9% Intravenous Solution work?

Sodium chloride 0.9% restores and maintains electrolyte balance and fluid volume in the body by providing isotonic saline solution.

What is Sodium Chloride 0.9% Intravenous Solution used for?

Sodium Chloride 0.9% Intravenous Solution is indicated for Fluid and electrolyte replacement in dehydration, Maintenance of fluid balance during surgery or acute illness, Vehicle for intravenous medication administration, Treatment of hypovolemia and shock.

Who makes Sodium Chloride 0.9% Intravenous Solution?

Sodium Chloride 0.9% Intravenous Solution is developed and marketed by Department of Medical Services Ministry of Public Health of Thailand (see full Department of Medical Services Ministry of Public Health of Thailand pipeline at /company/department-of-medical-services-ministry-of-public-health-of-thailand).

Is Sodium Chloride 0.9% Intravenous Solution also known as anything else?

Sodium Chloride 0.9% Intravenous Solution is also known as placebo comparator, Physiologic saline.

What drug class is Sodium Chloride 0.9% Intravenous Solution in?

Sodium Chloride 0.9% Intravenous Solution belongs to the Electrolyte replacement solution class. See all Electrolyte replacement solution drugs at /class/electrolyte-replacement-solution.

What development phase is Sodium Chloride 0.9% Intravenous Solution in?

Sodium Chloride 0.9% Intravenous Solution is FDA-approved (marketed).

What are the side effects of Sodium Chloride 0.9% Intravenous Solution?

Common side effects of Sodium Chloride 0.9% Intravenous Solution include Hyperchloremic acidosis, Fluid overload, Hypernatremia, Phlebitis at injection site.

Related

• Drug class: All Electrolyte replacement solution drugs
• Manufacturer: Department of Medical Services Ministry of Public Health of Thailand — full pipeline
• Therapeutic area: All drugs in Fluid and electrolyte management
• Indication: Drugs for Fluid and electrolyte replacement in dehydration
• Indication: Drugs for Maintenance of fluid balance during surgery or acute illness
• Indication: Drugs for Vehicle for intravenous medication administration
• Also known as: placebo comparator, Physiologic saline