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Phentermine and Topiramate
Phentermine and topiramate reduce appetite and food consumption through different mechanisms involving catecholamine release and neurotransmitter modulation.
At a glance
| Generic name | Phentermine and Topiramate |
|---|---|
| Sponsor | VIVUS LLC |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
Phentermine works by releasing catecholamines in the hypothalamus, which reduces appetite and decreases food intake. Topiramate's effects are less clear but may involve enhancing satiety and suppressing appetite through various pharmacologic actions.
Approved indications
- Obesity Management
- Overweight with Comorbidity Management
Common side effects
- Mood and sleep disorders
- Insomnia
- Paraesthesia
- Dizziness
- Dysgeusia
- Constipation
- Dry mouth
- Depression
- Anxiety
- Heart rate elevation
- Pyrexia
- Arthralgia
Drug interactions
- Monoamine Oxidase Inhibitors (MAOIs)
- Oral Contraceptives
- CNS Depressants Including Alcohol
- Non-Potassium Sparing Diuretics
Key clinical trials
- Preoperative Weight Loss for Open Abdominal Wall Reconstruction (NA)
- Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder (PHASE4)
- Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery (PHASE4)
- Weight Gain Prevention in Adolescents and Young Adults (PHASE3)
- Phentermine/Topiramate for Uric Acid Stones (PHASE3)
- A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America (PHASE4)
- Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease (PHASE4)
- Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Phentermine and Topiramate CI brief — competitive landscape report
- Phentermine and Topiramate updates RSS · CI watch RSS
- VIVUS LLC portfolio CI