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Pharmacological stress agents
Pharmacological stress agents is a Cardiac stress agents Small molecule drug developed by GE Healthcare. It is currently in Phase 3 development for Diagnostic imaging agent for assessment of myocardial perfusion and coronary artery disease, Evaluation of cardiac function in patients unable to perform exercise stress testing.
Pharmacological stress agents induce controlled cardiac stress through vasodilation or increased heart rate to assess myocardial perfusion and function during diagnostic imaging.
Pharmacological stress agents induce controlled cardiac stress through vasodilation or increased heart rate to assess myocardial perfusion and function during diagnostic imaging. Used for Diagnostic imaging agent for assessment of myocardial perfusion and coronary artery disease, Evaluation of cardiac function in patients unable to perform exercise stress testing.
At a glance
| Generic name | Pharmacological stress agents |
|---|---|
| Sponsor | GE Healthcare |
| Drug class | Cardiac stress agents |
| Target | Adenosine A2A receptor (adenosine); dopamine and beta-adrenergic receptors (dobutamine); adenosine A2A receptor (regadenoson) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
These agents (commonly adenosine, regadenoson, or dobutamine) simulate the hemodynamic effects of exercise stress without physical exertion, allowing visualization of coronary blood flow reserve and detection of ischemia. They are used in nuclear cardiology and echocardiography to evaluate patients who cannot undergo exercise stress testing, revealing areas of reduced perfusion that indicate coronary artery disease.
Approved indications
- Diagnostic imaging agent for assessment of myocardial perfusion and coronary artery disease
- Evaluation of cardiac function in patients unable to perform exercise stress testing
Common side effects
- Chest discomfort or angina
- Dyspnea
- Headache
- Flushing
- Palpitations
- Hypotension
- Arrhythmias
Key clinical trials
- The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study (NA)
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- Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD (PHASE1)
- Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes (NA)
- Neurobiological and Genomic Predictors of Relapse in Depression
- Randomised Controlled Trial of an Antioxidant and Sunscreen Combination Cream for Reducing DNA Damage in Human Skin (NA)
- Suvorexant for Opioid/Stimulant Co-use (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pharmacological stress agents CI brief — competitive landscape report
- Pharmacological stress agents updates RSS · CI watch RSS
- GE Healthcare portfolio CI
Frequently asked questions about Pharmacological stress agents
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Related
- Drug class: All Cardiac stress agents drugs
- Target: All drugs targeting Adenosine A2A receptor (adenosine); dopamine and beta-adrenergic receptors (dobutamine); adenosine A2A receptor (regadenoson)
- Manufacturer: GE Healthcare — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Diagnostic imaging agent for assessment of myocardial perfusion and coronary artery disease
- Indication: Drugs for Evaluation of cardiac function in patients unable to perform exercise stress testing
- Compare: Pharmacological stress agents vs similar drugs
- Pricing: Pharmacological stress agents cost, discount & access