Last reviewed 2026-04-22 · How we verify

Personalized DAPT duration

Personalized DAPT duration tailors the length of dual antiplatelet therapy (aspirin + P2Y12 inhibitor) to individual patient risk factors rather than using a fixed treatment duration.

Personalized DAPT duration tailors the length of dual antiplatelet therapy (aspirin plus P2Y12 inhibitor) to individual patient risk factors rather than using a fixed treatment duration. Used for Acute coronary syndrome with percutaneous coronary intervention and stent placement, Stable coronary artery disease with percutaneous coronary intervention and stent placement.

At a glance

Mechanism of action

This is a treatment strategy rather than a single drug entity. It involves customizing the duration of dual antiplatelet therapy based on patient-specific bleeding and ischemic risk profiles, typically assessed through clinical scoring systems or biomarkers. The approach aims to optimize the balance between reducing stent thrombosis risk and minimizing bleeding complications by individualizing therapy duration beyond standard 12-month protocols.

Approved indications

• Acute coronary syndrome (ACS) post-percutaneous coronary intervention (PCI) with stent placement
• Stable coronary artery disease post-PCI with stent placement

Common side effects

• Stent thrombosis
• Major bleeding
• Minor bleeding

Key clinical trials

• Pharmacogenomics in Stroke: Feasibility of CYP2C19 Testing (NA)
• Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES (PHASE4)
• STrategies of Scheduled Drug-coated Balloons (DCB) Versus Conventional DES for the interveNTional Therapy of de Novo Lesions in Large Coronary vESSels (STENTLESS) Trial (NA)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Personalized DAPT duration CI brief — competitive landscape report
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• Federico II University portfolio CI