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PerioChip ®
PerioChip releases chlorhexidine directly into periodontal pockets to reduce bacterial infection and inflammation in periodontal disease.
PerioChip releases chlorhexidine directly into periodontal pockets to reduce bacterial infection and inflammation in periodontal disease. Used for Adjunctive treatment of adult periodontitis.
At a glance
| Generic name | PerioChip ® |
|---|---|
| Sponsor | Dexcel Pharma Technologies Ltd. |
| Drug class | Local antimicrobial agent |
| Target | Bacterial cell membranes (chlorhexidine non-specific antimicrobial) |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Periodontics |
| Phase | FDA-approved |
Mechanism of action
PerioChip is a biodegradable chip containing chlorhexidine gluconate that is inserted into periodontal pockets where it provides sustained local delivery of the antimicrobial agent over several days. The chlorhexidine kills or inhibits periodontal pathogens, reducing pocket depth and bleeding on probing. This localized delivery approach achieves high drug concentrations at the site of infection while minimizing systemic exposure.
Approved indications
- Adjunctive treatment of adult periodontitis
Common side effects
- Tooth sensitivity
- Temporary discomfort at insertion site
- Allergic reaction to chlorhexidine
Key clinical trials
- Hyaluronic Gel vs Chlorhexidine in Periodontal Patients (NA)
- The Aim of This Study is to Compare the Effects of Two Different Topical Agents (KLOROBEN® and KLORHEX PLUS®) Used in the Surgical Extraction of Mandibular Bilateral Mesioangular Impacted Third Molars on Postoperative Pain, Edema, and Trismus. (NA)
- Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis. (PHASE4)
- Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery
- Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes (NA)
- Contact Activation of Coagulation in Newly Inserted Central Venous Catheters (NA)
- Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO) (PHASE2)
- Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |