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Peginterferon alfa-2a 40KD and Ribavirin

NORDynamIC Study Group · FDA-approved active Small molecule

Peginterferon alfa-2a 40KD and Ribavirin is a Interferon alpha with nucleoside analog Small molecule drug developed by NORDynamIC Study Group. It is currently FDA-approved for Chronic hepatitis C virus infection (genotype-dependent, now largely superseded by direct-acting antivirals).

Peginterferon alfa-2a activates interferon-alpha receptors to enhance antiviral immunity, while ribavirin inhibits viral RNA synthesis, together suppressing hepatitis C virus replication.

Peginterferon alfa-2a activates interferon-alpha receptors to enhance antiviral immunity, while ribavirin inhibits viral RNA synthesis, together suppressing hepatitis C virus replication. Used for Chronic hepatitis C virus infection (genotype-dependent, now largely superseded by direct-acting antivirals).

At a glance

Generic namePeginterferon alfa-2a 40KD and Ribavirin
SponsorNORDynamIC Study Group
Drug classInterferon alpha with nucleoside analog
TargetInterferon-alpha receptor (IFNAR); viral RNA-dependent RNA polymerase
ModalitySmall molecule
Therapeutic areaVirology / Hepatology
PhaseFDA-approved

Mechanism of action

Peginterferon alfa-2a is a long-acting interferon that binds to type I interferon receptors, triggering JAK-STAT signaling to induce antiviral and immunomodulatory responses. Ribavirin is a nucleoside analog that inhibits viral RNA-dependent RNA polymerase and may enhance T-cell responses. Together, this combination was the standard-of-care treatment for chronic hepatitis C before direct-acting antivirals became available.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Peginterferon alfa-2a 40KD and Ribavirin

What is Peginterferon alfa-2a 40KD and Ribavirin?

Peginterferon alfa-2a 40KD and Ribavirin is a Interferon alpha with nucleoside analog drug developed by NORDynamIC Study Group, indicated for Chronic hepatitis C virus infection (genotype-dependent, now largely superseded by direct-acting antivirals).

How does Peginterferon alfa-2a 40KD and Ribavirin work?

Peginterferon alfa-2a activates interferon-alpha receptors to enhance antiviral immunity, while ribavirin inhibits viral RNA synthesis, together suppressing hepatitis C virus replication.

What is Peginterferon alfa-2a 40KD and Ribavirin used for?

Peginterferon alfa-2a 40KD and Ribavirin is indicated for Chronic hepatitis C virus infection (genotype-dependent, now largely superseded by direct-acting antivirals).

Who makes Peginterferon alfa-2a 40KD and Ribavirin?

Peginterferon alfa-2a 40KD and Ribavirin is developed and marketed by NORDynamIC Study Group (see full NORDynamIC Study Group pipeline at /company/nordynamic-study-group).

What drug class is Peginterferon alfa-2a 40KD and Ribavirin in?

Peginterferon alfa-2a 40KD and Ribavirin belongs to the Interferon alpha with nucleoside analog class. See all Interferon alpha with nucleoside analog drugs at /class/interferon-alpha-with-nucleoside-analog.

What development phase is Peginterferon alfa-2a 40KD and Ribavirin in?

Peginterferon alfa-2a 40KD and Ribavirin is FDA-approved (marketed).

What are the side effects of Peginterferon alfa-2a 40KD and Ribavirin?

Common side effects of Peginterferon alfa-2a 40KD and Ribavirin include Flu-like symptoms (fever, fatigue, myalgia), Hemolytic anemia, Neutropenia, Thrombocytopenia, Depression and neuropsychiatric effects, Thyroid dysfunction.

What does Peginterferon alfa-2a 40KD and Ribavirin target?

Peginterferon alfa-2a 40KD and Ribavirin targets Interferon-alpha receptor (IFNAR); viral RNA-dependent RNA polymerase and is a Interferon alpha with nucleoside analog.

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