Last reviewed 2026-04-23 · How we verify

Peginterferon α2b

Peginterferon α2b works by stimulating the body's immune system to fight viral infections.

Peginterferon α2b works by stimulating the body's immune system to fight viral infections. Used for Chronic hepatitis C, Chronic hepatitis B.

At a glance

Mechanism of action

It does this by inducing the production of antiviral proteins and activating immune cells to target and eliminate infected cells. Peginterferon α2b is a pegylated form of interferon α2b, which allows for a longer duration of action and reduced dosing frequency.

Approved indications

• Chronic hepatitis C
• Chronic hepatitis B

Common side effects

• Flu-like symptoms
• Fatigue
• Headache

Key clinical trials

• Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma (PHASE2)
• Safety, Tolerability, and Preliminary Efficacy of Peginterferon α-2b in Combination With an Anti-PD-1 Antibody in Patients With Advanced or Metastatic Malignant Solid Tumors (NA)
• Peginterferon α-2b Injection for Hydroxyurea Resistant or Intolerant ET (PHASE2)
• Prospective Cohort Study on PEG-IFN-α-2b in Improving Clinical Cure Rate of Pediatric Patients With Chronic Hepatitis B (PHASE4)
• A Study on Peginterferon Alfa-2b Combined With NAs in Compensated HBV Cirrhosis (NA)
• Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.
• Clinical Trial of Pegylated Interferon α-2b Via Nebulization for Treatment of Hand, Foot, and Mouth Disease . (NA)
• Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients (PHASE4)

Primary sources

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