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paracetamol + pregabalin + dexamethasone
This combination reduces pain through acetaminophen's analgesic action, pregabalin's modulation of calcium channels to reduce neuropathic pain, and dexamethasone's anti-inflammatory effects.
This combination reduces pain through acetaminophen's analgesic action, pregabalin's modulation of calcium channels to reduce neuropathic pain, and dexamethasone's anti-inflammatory effects. Used for Acute and chronic pain management, Neuropathic pain, Postoperative pain with inflammatory component.
At a glance
| Generic name | paracetamol + pregabalin + dexamethasone |
|---|---|
| Also known as | Acetaminophen, Pregabalin, Dexamethasone |
| Sponsor | Glostrup University Hospital, Copenhagen |
| Drug class | Combination analgesic/neuropathic pain agent |
| Target | COX inhibition (paracetamol); voltage-gated calcium channels (pregabalin); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Neurology |
| Phase | FDA-approved |
Mechanism of action
Paracetamol inhibits prostaglandin synthesis in the central nervous system to provide analgesia. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing the release of excitatory neurotransmitters involved in pain signaling. Dexamethasone, a corticosteroid, suppresses inflammatory mediators and immune responses that contribute to pain and inflammation.
Approved indications
- Acute and chronic pain management
- Neuropathic pain
- Postoperative pain with inflammatory component
Common side effects
- Dizziness
- Somnolence
- Hepatotoxicity (paracetamol)
- Hyperglycemia (dexamethasone)
- Immunosuppression (dexamethasone)
- Weight gain (dexamethasone)
Key clinical trials
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair (PHASE4)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study (PHASE4)
- Pre vs Post Block in Total Knee Arthroplasty (TKA) (PHASE4)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Does IV Magnesium Improve Quality of Recovery With ERAS Protocols in Laparoscopic Colorectal Surgery? (PHASE3)
- PROUD Study - Preventing Opioid Use Disorders (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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