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Paracetamol + ibuprofen
Paracetamol and ibuprofen work synergistically to reduce pain and fever through complementary analgesic and anti-inflammatory pathways.
This combination product uses paracetamol to reduce fever and pain via central nervous system effects, and ibuprofen to inhibit cyclooxygenase enzymes, reducing inflammation and pain. Used for Mild to moderate pain, Fever reduction.
At a glance
| Generic name | Paracetamol + ibuprofen |
|---|---|
| Also known as | Ibumetin, Ibuprofen, ATC code: M01A E01, Paracetamol, Acetaminophen |
| Sponsor | Ullevaal University Hospital |
| Drug class | Analgesic/antipyretic combination |
| Target | COX-1, COX-2 (ibuprofen); prostaglandin synthesis pathway (paracetamol) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Fever reduction |
| Phase | FDA-approved |
Mechanism of action
Paracetamol inhibits prostaglandin synthesis in the central nervous system, reducing pain perception and fever. Ibuprofen is a non-selective COX inhibitor that reduces prostaglandin production peripherally and centrally, providing anti-inflammatory, analgesic, and antipyretic effects. The combination leverages both central and peripheral mechanisms for enhanced pain relief.
Approved indications
- Mild to moderate pain
- Fever reduction
- Headache
Common side effects
- Gastrointestinal upset
- Nausea
- Dyspepsia
- Hepatotoxicity (paracetamol at high doses)
- Renal impairment (ibuprofen)
Key clinical trials
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD) (NA)
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Study of the Contribution of Osteopathic Treatment to Classic Medical Management in Patients With Chronic Low Back Pain (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Selected Exercise Program on Upper Cross Syndrome Post-unilateral Mastectomy (NA)
- Phase 2 Herniorrhaphy Study for Opioid Elimination (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Paracetamol + ibuprofen CI brief — competitive landscape report
- Paracetamol + ibuprofen updates RSS · CI watch RSS
- Ullevaal University Hospital portfolio CI