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paracetamol codein
Paracetamol reduces fever and pain through inhibition of prostaglandin synthesis, while codeine acts as an opioid agonist to enhance analgesia.
Paracetamol reduces fever and pain through inhibition of prostaglandin synthesis, while codeine acts as an opioid agonist to enhance analgesia. Used for Moderate pain relief, Fever reduction.
At a glance
| Generic name | paracetamol codein |
|---|---|
| Also known as | Geralgine K tablet |
| Sponsor | Diskapi Yildirim Beyazit Education and Research Hospital |
| Drug class | Analgesic combination (paracetamol + opioid) |
| Target | COX enzymes (paracetamol); mu opioid receptor (codeine) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Paracetamol (acetaminophen) inhibits cyclooxygenase enzymes in the central nervous system, reducing prostaglandin production and thereby lowering pain perception and body temperature. Codeine is a weak opioid agonist that binds to mu opioid receptors in the brain and spinal cord, potentiating the analgesic effect. The combination provides synergistic pain relief for moderate pain conditions.
Approved indications
- Moderate pain relief
- Fever reduction
Common side effects
- Nausea
- Dizziness
- Constipation
- Drowsiness
- Hepatotoxicity (paracetamol overdose)
Key clinical trials
- Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain (PHASE4)
- Effectiveness of Conventional Therapy Plus Pulsed-Radiofrequency for Herniated Nucleus Pulposus (NA)
- An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery (NA)
- Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain (PHASE4)
- SB-705498 Dental Pain Study After Tooth Extraction (PHASE2)
- Idiopathic Intracranial Hypertension Treatment Trial (PHASE2, PHASE3)
- Bioequivalence Study of Co-codamol 15mg/500mg Capsules vs Co-codamol 30mg/500mg Tablets in Healthy Subjects (PHASE1)
- Protocol to Ease Acute Cephalalgia in Emergency-department (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- paracetamol codein CI brief — competitive landscape report
- paracetamol codein updates RSS · CI watch RSS
- Diskapi Yildirim Beyazit Education and Research Hospital portfolio CI