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Para-Toluenesulfonamide

Para-Toluenesulfonamide is a sulfonamide antibiotic that inhibits bacterial growth by disrupting folic acid synthesis.

Para-Toluenesulfonamide is a sulfonamide antibiotic that inhibits bacterial growth by disrupting folic acid synthesis. Used for Urinary tract infections, Pneumonia.

At a glance

Mechanism of action

Para-Toluenesulfonamide works by competitively inhibiting the enzyme dihydropteroate synthetase, which is necessary for the synthesis of tetrahydrofolate, a precursor to folic acid. This disruption prevents bacteria from producing folic acid, which is essential for DNA synthesis and cell division. As a result, bacterial growth is inhibited, and the infection is treated.

Approved indications

• Urinary tract infections
• Pneumonia

Common side effects

• Hemolysis
• Thrombocytopenia
• Nausea
• Vomiting
• Diarrhea

Key clinical trials

• First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion (PHASE1, PHASE2)
• A Study of PTS100 in Primary HCC Patients (PHASE2)
• A Study of PTS for Patients With Solid Tumors (PHASE1)
• A Trial of PTS Via Intratumoral Injection in Patients With Central Air Way NSCLC Severe Obstruction (PHASE3)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Para-Toluenesulfonamide CI brief — competitive landscape report
• Para-Toluenesulfonamide updates RSS · CI watch RSS
• Gongwin Biopharm Co., Ltd. portfolio CI