Last reviewed · How we verify
pamidronate
At a glance
| Generic name | pamidronate |
|---|---|
| Also known as | Aredia, ADP Sodium, Aredia®, Aridia, Transplant Bone Disease |
| Sponsor | US Department of Veterans Affairs |
| Target | Farnesyl pyrophosphate synthase, Farnesyl pyrophosphate synthase, Hypoxanthine-guanine phosphoribosyltransferase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Approved indications
- Humoral hypercalcemia of malignancy
- Osteitis deformans
- Osteolytic Bone Metastases of Breast Cancer
- Osteolytic Lesions of Multiple Myeloma
Common side effects
- Fever
- Nausea
- Infusion-site reaction
- Hypokalemia
- Hypophosphatemia
- Fatigue
- Anorexia
- Hypocalcemia
- Hypomagnesemia
- Constipation
- Moniliasis
- Gastrointestinal hemorrhage
Serious adverse events
- Seizures
- Uveitis
- Iritis
- Scleritis
- Episcleritis
- Cardiac failure
- Gastrointestinal hemorrhage
- Hypothyroidism
- Transient elevation of temperature
- Local soft-tissue reactions at catheter site
Key clinical trials
- Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer (PHASE4)
- Complex Regional Pain Syndrome: Analgesic Outcome
- CHronic Nonbacterial Osteomyelitis International Registry
- Effect of Local Pamidronate in Preventing Bone Loss After Total Hip Arthroplasty (PHASE1)
- Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation (PHASE2)
- Prevention of Post Operative Bone Loss in Children (NA)
- Pamidronate Administration in Breast Cancer Patients With Bone Metastases (PHASE4)
- Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |