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paclitaxel/Gemcitabine/Liposomal doxorubicin
paclitaxel/Gemcitabine/Liposomal doxorubicin is a Taxane, Nucleoside analog, Anthracycline antibiotic Small molecule drug developed by Innovent Biologics (Suzhou) Co. Ltd.. It is currently in Phase 3 development for Metastatic breast cancer, Metastatic pancreatic cancer, Metastatic ovarian cancer.
Paclitaxel inhibits microtubule dynamics, Gemcitabine is a nucleoside analog that inhibits DNA synthesis, and Liposomal doxorubicin is an anthracycline antibiotic that intercalates DNA.
Paclitaxel inhibits microtubule dynamics, Gemcitabine is a nucleoside analog that inhibits DNA synthesis, and Liposomal doxorubicin is an anthracycline antibiotic that intercalates DNA. Used for Metastatic breast cancer, Metastatic pancreatic cancer, Metastatic ovarian cancer.
At a glance
| Generic name | paclitaxel/Gemcitabine/Liposomal doxorubicin |
|---|---|
| Sponsor | Innovent Biologics (Suzhou) Co. Ltd. |
| Drug class | Taxane, Nucleoside analog, Anthracycline antibiotic |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Paclitaxel stabilizes microtubules, preventing cell division, while Gemcitabine is incorporated into DNA, causing chain termination. Liposomal doxorubicin's intercalation into DNA inhibits topoisomerase II, leading to DNA damage and apoptosis.
Approved indications
- Metastatic breast cancer, Metastatic pancreatic cancer, Metastatic ovarian cancer
Common side effects
- Neutropenia
- Anemia
- Thrombocytopenia
- Fatigue
- Nausea
- Vomiting
Key clinical trials
- Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial (PHASE2)
- Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression (PHASE3)
- A Two-Part Phase 3 Study of Sofetabart Mipitecan (LY4170156) in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Part B) Ovarian Cancer (PHASE3)
- A Study to Investigate GSK5733584 Compared With Chemotherapy in Participants With Platinum-resistant Ovarian Cancer (BEHOLD-Ovarian01) (PHASE3)
- Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076) (PHASE3)
- Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Pancreatic Cancer (EARLY_PHASE1)
- Testing the Use of A Single Drug (Olaparib) or the Combination of Two Drugs (Cediranib and Olaparib) Compared to the Usual Chemotherapy for Women With Platinum Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (PHASE3)
- Testing the Combination of Cediranib and Olaparib in Comparison to Each Drug Alone or Other Chemotherapy in Recurrent Platinum-Resistant Ovarian Cancer (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- paclitaxel/Gemcitabine/Liposomal doxorubicin CI brief — competitive landscape report
- paclitaxel/Gemcitabine/Liposomal doxorubicin updates RSS · CI watch RSS
- Innovent Biologics (Suzhou) Co. Ltd. portfolio CI
Frequently asked questions about paclitaxel/Gemcitabine/Liposomal doxorubicin
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Related
- Drug class: All Taxane, Nucleoside analog, Anthracycline antibiotic drugs
- Manufacturer: Innovent Biologics (Suzhou) Co. Ltd. — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic breast cancer, Metastatic pancreatic cancer, Metastatic ovarian cancer
- Compare: paclitaxel/Gemcitabine/Liposomal doxorubicin vs similar drugs
- Pricing: paclitaxel/Gemcitabine/Liposomal doxorubicin cost, discount & access