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Oxygen + Midazolam
Oxygen increases blood oxygen saturation while midazolam provides sedation and anxiolysis via GABA-A receptor modulation.
Oxygen increases blood oxygen saturation while midazolam provides sedation and anxiolysis via GABA-A receptor modulation. Used for Procedural sedation and anxiolysis during medical procedures, Maintenance of oxygenation during sedated procedures.
At a glance
| Generic name | Oxygen + Midazolam |
|---|---|
| Sponsor | Unity Health Toronto |
| Drug class | Supportive care combination (oxygen + benzodiazepine) |
| Target | GABA-A receptor (midazolam component) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Procedural Sedation |
| Phase | FDA-approved |
Mechanism of action
This is a supportive care combination used during medical procedures. Oxygen ensures adequate oxygenation and prevents hypoxemia, while midazolam, a benzodiazepine, binds to GABA-A receptors in the central nervous system to produce sedation, anxiolysis, and amnesia. Together they enable safe procedural sedation with maintained oxygenation.
Approved indications
- Procedural sedation and anxiolysis during medical procedures
- Maintenance of oxygenation during sedated procedures
Common side effects
- Respiratory depression
- Hypotension
- Oversedation
- Paradoxical agitation
Key clinical trials
- SMILE Trial - Imaging Sub-Study
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound (NA)
- Changes of Ciprofol Dosage and Bispectral Index Required for Loss of Consciousness in Patients of Different Ages
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation (NA)
- Comparison of the Effects of Target-Controlled Infusion Method and Manual Propofol Administration on Respiratory Function, Recovery, and Electroencephalogram in Endoscopic Submucosal Dissection Cases (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oxygen + Midazolam CI brief — competitive landscape report
- Oxygen + Midazolam updates RSS · CI watch RSS
- Unity Health Toronto portfolio CI