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Oxycodone, fentanyl
This is a combination of two opioid agonists that bind to mu-opioid receptors in the central nervous system to produce analgesia and pain relief.
This is a combination of two opioid agonists that bind to mu-opioid receptors in the central nervous system to produce analgesia and pain relief. Used for Moderate to severe pain, Chronic pain management.
At a glance
| Generic name | Oxycodone, fentanyl |
|---|---|
| Sponsor | Danish Pain Research Center |
| Drug class | Opioid agonist combination |
| Target | Mu-opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Oxycodone is a semi-synthetic opioid agonist that binds to mu-opioid receptors, while fentanyl is a synthetic opioid agonist with higher potency and faster onset. Together, they provide enhanced pain relief through complementary pharmacokinetic profiles. This combination is used in pain management, leveraging oxycodone's oral bioavailability and fentanyl's rapid action and potency.
Approved indications
- Moderate to severe pain management
- Chronic pain conditions
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Respiratory depression
- Dependence/addiction risk
Key clinical trials
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Effectiveness of Percutaneous Neuromodulation vs Pharmacological Treatment in Cancer Patients With Anterior Knee Pain (NA)
- Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation
- The Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lobectomy (PHASE4)
- Effect of Postoperative Analgesia of Oliceridine Fumarate for Gastrointestinal Function Recovery in Patients Undergoing Lumbar Spine Surgery (NA)
- Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose (NA)
- Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies (NA)
- Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oxycodone, fentanyl CI brief — competitive landscape report
- Oxycodone, fentanyl updates RSS · CI watch RSS
- Danish Pain Research Center portfolio CI