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ovarian stimulation
Ovarian stimulation uses gonadotropins or other hormonal agents to induce the development and release of multiple oocytes from the ovaries for assisted reproductive procedures.
Ovarian stimulation uses gonadotropins or other hormonal agents to induce the development and release of multiple oocytes from the ovaries for assisted reproductive procedures. Used for Infertility in women undergoing assisted reproductive technology (ART), Anovulation or oligoovulation in women seeking pregnancy.
At a glance
| Generic name | ovarian stimulation |
|---|---|
| Also known as | controlled ovarian hyperstimulatiom, Follitropine (Puregon), Ganirelix (Orgalutran), Triptoreline (Decapeptyl) |
| Sponsor | Ain Shams Maternity Hospital |
| Drug class | Gonadotropin |
| Target | FSH receptor, LH receptor |
| Modality | Small molecule |
| Therapeutic area | Reproductive Medicine / Fertility |
| Phase | FDA-approved |
Mechanism of action
Ovarian stimulation typically involves administration of follicle-stimulating hormone (FSH), luteinizing hormone (LH), or human menopausal gonadotropin (hMG) to promote the growth of multiple ovarian follicles. This controlled hyperstimulation allows retrieval of multiple eggs during in vitro fertilization (IVF) or other fertility treatments, increasing the chances of successful conception by providing more oocytes for fertilization.
Approved indications
- Infertility in women undergoing assisted reproductive technology (ART)
- Anovulation or oligoovulation in women seeking pregnancy
Common side effects
- Ovarian hyperstimulation syndrome (OHSS)
- Abdominal pain and bloating
- Headache
- Nausea
- Injection site reactions
Key clinical trials
- Efficacy of Micronized Natural Progesterone vs GnRH Antagonist in the Prevention of LH Peak During Ovarian Stimulation. (PHASE4)
- FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea (PHASE3)
- PPOS vs GnRH Antagonist in Ovarian Stimulation (ProGanOS Study) (NA)
- INTEnsity of ovariaN Stimulation and Embryo Quality (PHASE4)
- BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)
- Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer. (PHASE3)
- Automation of the In Vitro Fertilization Laboratory (NA)
- Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |