Last reviewed 2026-04-23 · How we verify

Otosynalar®

Otosynalar is a topical corticosteroid-antibiotic combination that reduces inflammation and treats bacterial infection in the ear canal.

Otosynalar is a topical corticosteroid-antibiotic combination that reduces inflammation and treats bacterial infection in the ear canal. Used for Acute otitis externa (swimmer's ear), Bacterial infection of the external ear canal with inflammation.

At a glance

Mechanism of action

The formulation combines a corticosteroid (typically neomycin and dexamethasone or similar agents) to suppress inflammatory response and reduce swelling in otitis externa, paired with an antibiotic component to address bacterial infection. This dual action addresses both the infectious and inflammatory components of ear canal disease.

Approved indications

• Acute otitis externa (swimmer's ear)
• Bacterial infection of the external ear canal with inflammation

Common side effects

• Local irritation or sensitization
• Allergic contact dermatitis
• Secondary infection

Key clinical trials

• Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis. (PHASE3)

Primary sources

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