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Oral Glucose Tolerance Test
The Oral Glucose Tolerance Test (OGTT) is a diagnostic procedure that measures the body's ability to regulate blood glucose by administering a standardized glucose load and monitoring plasma glucose levels over time.
The Oral Glucose Tolerance Test (OGTT) is a diagnostic procedure that measures how the body processes glucose by administering a standardized glucose dose orally and measuring blood glucose levels over time. Used for Screening and diagnosis of type 2 diabetes mellitus, Diagnosis of gestational diabetes mellitus, Assessment of glucose intolerance and prediabetes.
At a glance
| Generic name | Oral Glucose Tolerance Test |
|---|---|
| Also known as | Glucose Drink 100, OGTT |
| Sponsor | University of Florida |
| Modality | Small molecule |
| Therapeutic area | Diagnostics / Endocrinology |
| Phase | FDA-approved |
Mechanism of action
The OGTT involves fasting overnight, consuming a standardized oral glucose solution (typically 75g), and measuring blood glucose at baseline and at intervals (usually 2 hours) to assess glucose metabolism and insulin response. This test evaluates pancreatic beta-cell function and peripheral insulin sensitivity, helping to diagnose impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes mellitus.
Approved indications
- Screening and diagnosis of type 2 diabetes mellitus
- Diagnosis of impaired glucose tolerance and prediabetes
- Assessment of gestational diabetes mellitus
Common side effects
- Nausea
- Abdominal discomfort
- Dizziness
Key clinical trials
- Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance (PHASE4)
- Pilot Study of Continuous Glucose Monitoring for Postpartum Glucose Screening (NA)
- Peri-operative Dynamics of the Growth Hormone Axis in Subjects With Acromegaly
- OGTT at Home Using CGM vs at the Clinic (NA)
- Imprinting in Metabolic Diseases - Identifying Epigenetic Mechanisms in Human Gestational Diabetes Through Cell-free DNA
- Study for the Identification of a Score to Assess Intrapancreatic Fat Through Eco-Elastography and Its Correlation With Metabolic Syndrome and Insulin-Secreting Cells. (NA)
- Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF
- Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oral Glucose Tolerance Test CI brief — competitive landscape report
- Oral Glucose Tolerance Test updates RSS · CI watch RSS
- University of Florida portfolio CI