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Oral capsule faecal microbiota transplantation
Oral capsule faecal microbiota transplantation is a Biologic drug developed by Tan Tock Seng Hospital. It is currently in Phase 3 development for Treatment-resistant Clostridioides difficile infection, Ulcerative colitis, Irritable bowel syndrome. Also known as: capsule FMT, FMT.
Oral capsule faecal microbiota transplantation involves the transfer of live microbes from a donor into the patient's gastrointestinal tract to restore a healthy balance of gut bacteria.
Oral capsule faecal microbiota transplantation involves the transfer of live microbes from a donor into the patient's gastrointestinal tract to restore a healthy balance of gut bacteria. Used for Treatment-resistant Clostridioides difficile infection, Ulcerative colitis, Irritable bowel syndrome.
At a glance
| Generic name | Oral capsule faecal microbiota transplantation |
|---|---|
| Also known as | capsule FMT, FMT |
| Sponsor | Tan Tock Seng Hospital |
| Modality | Biologic |
| Therapeutic area | Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
This process aims to treat various conditions by introducing beneficial microbes that can help to crowd out pathogenic bacteria, promoting a balanced gut microbiome. The exact mechanisms of action are not fully understood, but it is thought to involve the modulation of the immune system and the production of certain metabolites.
Approved indications
- Treatment-resistant Clostridioides difficile infection
- Ulcerative colitis
- Irritable bowel syndrome
Common side effects
- Abdominal pain
- Diarrhea
- Nausea
Key clinical trials
- LND101 for Fecal Microbiota Transplantation in Combination With Immune Checkpoint Blockade in Advanced Melanoma (PHASE2)
- Effect of Oral Microbiota on MDRO Decolonization (PHASE1, PHASE2)
- Study of Healthy Donor FMT (hdFMT) and Pembrolizumab in Relapsed/Refractory (R/R) PD-L1 Positive NSCLC (PHASE2)
- Using Healthy Gut Bacteria to Boost Immune Treatment for Advanced Bowel Cancer (EARLY_PHASE1)
- Fecal Microbiota Transplantation for Primary Sclerosing Cholangitis - Randomized Study Versus Sham Transplantation (PHASE2)
- PULSAR Combined With Fecal Microbiota Transplantation for Advanced Hepatocellular Carcinoma Progressing After First-Line Targeted-Immunotherapy (PHASE2)
- Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative Colitis (PHASE2)
- FMT Capsules for rCDI (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oral capsule faecal microbiota transplantation CI brief — competitive landscape report
- Oral capsule faecal microbiota transplantation updates RSS · CI watch RSS
- Tan Tock Seng Hospital portfolio CI
Frequently asked questions about Oral capsule faecal microbiota transplantation
What is Oral capsule faecal microbiota transplantation?
How does Oral capsule faecal microbiota transplantation work?
What is Oral capsule faecal microbiota transplantation used for?
Who makes Oral capsule faecal microbiota transplantation?
Is Oral capsule faecal microbiota transplantation also known as anything else?
What development phase is Oral capsule faecal microbiota transplantation in?
What are the side effects of Oral capsule faecal microbiota transplantation?
Related
- Manufacturer: Tan Tock Seng Hospital — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Treatment-resistant Clostridioides difficile infection
- Indication: Drugs for Ulcerative colitis
- Indication: Drugs for Irritable bowel syndrome
- Also known as: capsule FMT, FMT
- Compare: Oral capsule faecal microbiota transplantation vs similar drugs
- Pricing: Oral capsule faecal microbiota transplantation cost, discount & access