Last reviewed · How we verify
onabotulinumtoxinA 44 U
onabotulinumtoxinA 44 U works by temporarily paralyzing muscles to treat various conditions.
onabotulinumtoxinA 44 U works by temporarily paralyzing muscles to treat various conditions. Used for Blepharospasm, Strabismus, Cervical dystonia.
At a glance
| Generic name | onabotulinumtoxinA 44 U |
|---|---|
| Also known as | BOTOX®, BOTOX® Cosmetic, onabotulinumtoxinA |
| Sponsor | Allergan |
| Drug class | botulinum toxin |
| Target | acetylcholine release |
| Modality | Biologic |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
It does this by blocking the release of acetylcholine, a neurotransmitter that signals muscle contraction. This results in a temporary reduction in muscle activity, which can help alleviate symptoms of conditions such as blepharospasm, strabismus, and cervical dystonia.
Approved indications
- Blepharospasm
- Strabismus
- Cervical dystonia
- Hemifacial spasm
- Spasticity
- Hyperhidrosis
- Aesthetic uses (e.g. facial wrinkles)
Common side effects
- Eyelid ptosis
- Diplopia
- Headache
- Facial asymmetry
Key clinical trials
- Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines and Frown Lines (PHASE3)
- BOTOX® in the Treatment of Upper Facial Lines in Japan (PHASE3)
- Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines and Frown Lines (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |