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Omega-3 Supplementation
Omega-3 Supplementation is a Dietary supplement / Lipid-modifying agent Small molecule drug developed by Università degli Studi di Brescia. It is currently FDA-approved for Hypertriglyceridemia, Cardiovascular disease prevention, Rheumatoid arthritis. Also known as: Omega Brite, Ener Zone Omega 3 RX® Equipe Enervit.
Omega-3 fatty acids reduce triglycerides and modulate inflammatory pathways by competing with arachidonic acid metabolism and inhibiting pro-inflammatory eicosanoid production.
Omega-3 fatty acids reduce triglycerides and modulate inflammatory pathways by incorporating into cell membranes and affecting eicosanoid production. Used for Hypertriglyceridemia, Cardiovascular disease prevention, Inflammatory conditions.
At a glance
| Generic name | Omega-3 Supplementation |
|---|---|
| Also known as | Omega Brite, Ener Zone Omega 3 RX® Equipe Enervit |
| Sponsor | Università degli Studi di Brescia |
| Drug class | Dietary supplement / Lipid-modifying agent |
| Target | GPR120, GPR40, PPAR-γ, NF-κB signaling pathway |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Omega-3 polyunsaturated fatty acids (EPA and DHA) are incorporated into cell membranes and serve as substrates for the production of anti-inflammatory mediators (resolvins, protectins, lipoxins) while displacing arachidonic acid-derived pro-inflammatory eicosanoids. They also activate GPR120 and other G-protein coupled receptors, reduce NF-κB signaling, and lower hepatic triglyceride synthesis through AMPK activation and reduced SREBP-1c expression.
Approved indications
- Hypertriglyceridemia
- Cardiovascular disease prevention
- Rheumatoid arthritis
- Inflammatory bowel disease
Common side effects
- Gastrointestinal upset (nausea, diarrhea, dyspepsia)
- Fish aftertaste
- Bleeding tendency (at high doses)
- Headache
Key clinical trials
- Pre-Surgical Immunonutrition's Effect on Colorectal Surgery (NA)
- Omega-3 Supplementation vs Demodex vs Eyelid Cleanser for Pediatric Chalazia (PHASE2)
- FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM) (PHASE2)
- Can People Achieve a Target Omega-3 Index by Following a Personalized Omega-3 Dosing Regimen? (NA)
- Impact of an Omega-3 Enriched Oral Nutritional Supplement on Improving Surgical Outcomes in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery (NA)
- Omega-3 Supplementation and Mental Health in College Students (NA)
- The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac Surgery (PHASE2)
- Long-Term Omega-3 and Omega-3 Index >8%: Effects on Physiological Recovery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Omega-3 Supplementation CI brief — competitive landscape report
- Omega-3 Supplementation updates RSS · CI watch RSS
- Università degli Studi di Brescia portfolio CI
Frequently asked questions about Omega-3 Supplementation
What is Omega-3 Supplementation?
How does Omega-3 Supplementation work?
What is Omega-3 Supplementation used for?
Who makes Omega-3 Supplementation?
Is Omega-3 Supplementation also known as anything else?
What drug class is Omega-3 Supplementation in?
What development phase is Omega-3 Supplementation in?
What are the side effects of Omega-3 Supplementation?
What does Omega-3 Supplementation target?
Related
- Drug class: All Dietary supplement / Lipid-modifying agent drugs
- Target: All drugs targeting GPR120, GPR40, PPAR-γ, NF-κB signaling pathway
- Manufacturer: Università degli Studi di Brescia — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertriglyceridemia
- Indication: Drugs for Cardiovascular disease prevention
- Indication: Drugs for Rheumatoid arthritis
- Also known as: Omega Brite, Ener Zone Omega 3 RX® Equipe Enervit
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing