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Omega-3 fatty acid ethyl esters
Activates peroxisome proliferator-activated receptor alpha (PPAR-alpha)
Activates peroxisome proliferator-activated receptor alpha (PPAR-alpha) Used for Hypertriglyceridemia.
At a glance
| Generic name | Omega-3 fatty acid ethyl esters |
|---|---|
| Also known as | Lotriga Granular Capsules, Lotriga granular capsules |
| Sponsor | Takeda |
| Drug class | Fatty acid ethyl ester |
| Target | PPAR-alpha |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 2 |
Mechanism of action
Omega-3 fatty acid ethyl esters are known to reduce inflammation by activating PPAR-alpha, which regulates lipid metabolism.
Approved indications
- Hypertriglyceridemia
Common side effects
- Nausea
- Abdominal pain
- Diarrhea
Key clinical trials
- Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction (PHASE2)
- The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac Surgery (PHASE2)
- Phase II Trial to Modulate Intermediate Endpoint Biomarkers in Former and Current Smokers (PHASE2)
- Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers (NA)
- VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture (VITAL) (NA)
- VITamin D and OmegA-3 TriaL (VITAL): Fractures, Vitamin D and Genetic Markers (NA)
- VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone (VITAL) (NA)
- Vitamin D and Omega-3 Hypertension Trial (VITAL Hypertension) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Omega-3 fatty acid ethyl esters CI brief — competitive landscape report
- Omega-3 fatty acid ethyl esters updates RSS · CI watch RSS
- Takeda portfolio CI