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Olanzapine-samidorphan + exercise
Olanzapine-samidorphan combines an atypical antipsychotic (olanzapine) with a mu-opioid receptor antagonist (samidorphan) to treat schizophrenia and bipolar disorder while mitigating weight gain, with exercise as a behavioral intervention.
Olanzapine-samidorphan combines an atypical antipsychotic with a mu-opioid receptor antagonist to reduce antipsychotic-induced weight gain while maintaining psychiatric symptom control. Used for Schizophrenia with weight gain risk, Bipolar disorder with weight gain risk.
At a glance
| Generic name | Olanzapine-samidorphan + exercise |
|---|---|
| Sponsor | New York State Psychiatric Institute |
| Drug class | Atypical antipsychotic with opioid antagonist |
| Target | Dopamine receptors, serotonin receptors (olanzapine); mu-opioid receptor (samidorphan) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | FDA-approved |
Mechanism of action
Olanzapine acts as a dopamine and serotonin antagonist to manage psychotic symptoms, but commonly causes weight gain and metabolic dysfunction. Samidorphan is a mu-opioid receptor antagonist that blocks opioid-mediated appetite stimulation and metabolic effects, reducing olanzapine-induced weight gain. Exercise serves as an additional non-pharmacological intervention to further improve metabolic outcomes and overall health.
Approved indications
- Schizophrenia
- Bipolar I disorder
Common side effects
- Weight gain
- Sedation
- Metabolic dysfunction
- Akathisia
- Orthostatic hypotension
Key clinical trials
- Exercise and Olanzapine-samidorphan (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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