Last reviewed · How we verify
Ocular lubricant
Ocular lubricant is a Ophthalmic lubricant Small molecule drug developed by Ophthalmic Consultants of Long Island. It is currently FDA-approved for Dry eye syndrome / Keratoconjunctivitis sicca, Ocular surface irritation and discomfort.
Ocular lubricants reduce friction and provide moisture to the ocular surface by forming a protective film over the cornea and conjunctiva.
Ocular lubricant is a marketed topical ophthalmic formulation developed by Ophthalmic Consultants of Long Island for the treatment of dry eye disease and related ocular surface conditions. The product functions as a lubricating agent that restores the tear film and provides symptomatic relief through hydration and protection of the corneal and conjunctival surfaces. Currently in the marketed phase with no active FDA label data available, the drug has been evaluated across 50 clinical trials spanning Phase 1 through Phase 4, with particular focus on dry eye syndrome efficacy and safety. Key clinical differentiation emerges from comparative studies against established lubricants (Artelac® Nighttime Gel) and emerging formulations (nanoemulsions, sodium hyaluronate variants), demonstrating tolerability and efficacy in diverse patient populations including pediatric and geriatric cohorts. The ocular lubricant market represents a substantial commercial opportunity within the broader dry eye disease segment, with multiple formulation variants and delivery mechanisms under investigation. Pipeline expansion includes novel delivery systems and combination therapies with anti-inflammatory agents, positioning the product within a competitive landscape dominated by established players and emerging biotechnology innovators.
At a glance
| Generic name | Ocular lubricant |
|---|---|
| Sponsor | Ophthalmic Consultants of Long Island |
| Drug class | Ophthalmic lubricant |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Ocular lubricants work by supplementing natural tear film, which is essential for maintaining corneal health, comfort, and clarity of vision. They reduce evaporation of tears, protect the epithelial surface from mechanical irritation, and provide lubrication to allow smooth eyelid movement. These products are typically composed of viscous agents such as carboxymethylcellulose, hyaluronic acid, or mineral oil that mimic the properties of natural tears.
Approved indications
- Dry eye syndrome / Keratoconjunctivitis sicca
- Ocular surface irritation and discomfort
Common side effects
- Transient blurred vision
- Eye irritation or stinging
- Allergic reaction (rare)
Key clinical trials
- A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease (PHASE3)
- A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression (PHASE2)
- FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial (PHASE3)
- Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD (NA)
- Traditional Chinese Medicine Ultrasonic Atomization Treatment for Dry Eye Disease (NA)
- A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes (PHASE3)
- YM-101 Eye Drops in the Treatment of Dry Eye Syndrome (EARLY_PHASE1)
- An Evaluation of the Safety and Tolerability of Ocular Lubricants (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ocular lubricant CI brief — competitive landscape report
- Ocular lubricant updates RSS · CI watch RSS
- Ophthalmic Consultants of Long Island portfolio CI
Frequently asked questions about Ocular lubricant
What is Ocular lubricant?
How does Ocular lubricant work?
What is Ocular lubricant used for?
Who makes Ocular lubricant?
What drug class is Ocular lubricant in?
What development phase is Ocular lubricant in?
What are the side effects of Ocular lubricant?
Related
- Drug class: All Ophthalmic lubricant drugs
- Manufacturer: Ophthalmic Consultants of Long Island — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Dry eye syndrome / Keratoconjunctivitis sicca
- Indication: Drugs for Ocular surface irritation and discomfort
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing