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NSAID therapy
NSAIDs inhibit cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
NSAIDs inhibit cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. Used for Mild to moderate pain, Inflammation and fever, Rheumatoid arthritis.
At a glance
| Generic name | NSAID therapy |
|---|---|
| Sponsor | Rabin Medical Center |
| Drug class | Non-steroidal anti-inflammatory drug (NSAID) |
| Target | Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Rheumatology, Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
NSAIDs block COX-1 and/or COX-2 enzymes, which catalyze the production of prostaglandins and thromboxanes from arachidonic acid. By reducing these inflammatory mediators, NSAIDs provide analgesic, anti-inflammatory, and antipyretic effects. Different NSAIDs vary in their selectivity for COX-1 versus COX-2, which influences both efficacy and side effect profiles.
Approved indications
- Mild to moderate pain
- Inflammation and fever
- Rheumatoid arthritis
- Osteoarthritis
- Cardiovascular protection (low-dose aspirin)
Common side effects
- Gastrointestinal bleeding or ulceration
- Dyspepsia
- Nausea
- Renal impairment
- Cardiovascular events (with chronic use)
- Hypersensitivity reactions
Key clinical trials
- Study of Nonsteroidal Anti-inflammatory Drugs in People With Painful Knee Osteoarthritis (PHASE4)
- Ear Pressure Points Plus Pain Meds for Faster Kidney Stone Pain Relief (NA)
- Metformin Safety and Efficacy in Osteoarthritis. (PHASE3)
- KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism (NA)
- Association of Erectile Dysfunction With Neuropathic Pain, Disease Activity, and Functional Status in Male Patients With Axial Spondyloarthritis: A Cross-Sectional Observational Study
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Effect of Vitamin C on Pain Reduction After an Emergency Department Visit (NA)
- Helping Osteoarthritis Patients to Walk With NSAID (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- NSAID therapy CI brief — competitive landscape report
- NSAID therapy updates RSS · CI watch RSS
- Rabin Medical Center portfolio CI