Last reviewed 2026-04-22 · How we verify

NSAID (Aceclofenac)

Aceclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.

Aceclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis.

At a glance

Mechanism of action

As a nonsteroidal anti-inflammatory drug (NSAID), aceclofenac preferentially inhibits COX-2 while also affecting COX-1, suppressing the production of pro-inflammatory prostaglandins. This mechanism reduces pain, inflammation, and fever. Aceclofenac is a prodrug that is metabolized to diclofenac, which accounts for much of its pharmacological activity.

Approved indications

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Acute pain and inflammation

Common side effects

• Gastrointestinal disorders (dyspepsia, abdominal pain, nausea)
• Headache
• Dizziness
• Rash
• Elevated liver enzymes

Key clinical trials

• Effects of App-assisted Home Exercise Program in Patients With Frozen Shoulder (NA)
• Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Naproxen, Aceclofenac, Celecoxib and Ilaprazole (PHASE1)
• Comparative Effectiveness Study for Surgery vs. Non-Surgery in Patients With Low Back Pain (NA)
• A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601 (PHASE4)
• A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis (PHASE4)

Primary sources

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