Last reviewed 2026-04-22 · How we verify

normal saline plus hyruan

Normal saline combined with hyaluronic acid (Hyruan) provides hydration and viscoelastic lubrication to tissues.

Normal saline combined with hyaluronic acid (Hyruan) provides hydration and viscoelastic lubrication to tissues. Used for Dry eye syndrome, Ocular surface lubrication, Joint lubrication and protection.

At a glance

Mechanism of action

This combination uses normal saline as a physiologic carrier solution paired with hyaluronic acid, a naturally occurring polysaccharide that provides viscosity and tissue protection. Hyaluronic acid acts as a lubricant and hydrating agent, commonly used in ophthalmic and orthopedic applications to reduce friction and maintain moisture in affected tissues.

Approved indications

• Dry eye syndrome
• Ocular surface lubrication
• Joint lubrication and protection

Common side effects

• Mild ocular irritation
• Temporary blurred vision
• Allergic reaction

Key clinical trials

• Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis (PHASE4)
• Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss (PHASE1, PHASE2)
• Is Combined Steroid and Sodium Hyaluronate Hydrodilatation More Effective Than Isolated Steroid Hydrodilatation in Treating Patients With Adhesive Capsulitis (NA)
• Effects of Knee Injections on Patients With Knee Osteoarthritis (PHASE4)
• Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis (PHASE3)

Primary sources

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