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Normal saline irrigation
Normal saline irrigation mechanically cleanses and flushes wounds or surgical sites with sterile 0.9% sodium chloride solution to remove debris, bacteria, and foreign material.
Normal saline irrigation mechanically cleanses and flushes wounds or surgical sites with sterile 0.9% sodium chloride solution to remove debris, bacteria, and foreign material. Used for Wound irrigation and cleansing, Surgical site irrigation, Post-operative wound management.
At a glance
| Generic name | Normal saline irrigation |
|---|---|
| Also known as | Intraperitoneal Normal saline irrigation, Saline irrigation |
| Sponsor | Hospital General Universitario Elche |
| Drug class | Wound irrigation solution |
| Modality | Small molecule |
| Therapeutic area | Surgery / Wound Care |
| Phase | Phase 3 |
Mechanism of action
Normal saline (0.9% NaCl) is an isotonic solution that matches physiological osmolarity, making it safe for direct tissue contact. When used for irrigation, it physically removes contaminants, necrotic tissue, and microorganisms from wounds or surgical fields without causing cellular damage or electrolyte imbalance. The mechanical flushing action promotes wound healing and reduces infection risk.
Approved indications
- Wound irrigation and cleansing
- Surgical site irrigation
- Post-operative wound management
Common side effects
- Minimal systemic adverse events expected with topical use
Key clinical trials
- Effects of Bronchial Segmental Endotoxin Instillation in Humans (PHASE2)
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- New Techniques for Using a Saline Wash as a Diagnostic Tool for Pneumocystis Pneumonia
- Volume Reduction for Open Fracture Irrigation (PHASE4)
- Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity (PHASE2, PHASE3)
- The Impact of Saline Temperature and Local Anesthetic Adjuvants on Postoperative Shoulder Pain and Inflammatory Marker Levels Following Laparoscopic Cholecystectomy (NA)
- Evaluating Postoperative Pain and Antibacterial Effect of Ultrasonic and 980 nm Diode Laser Combination (NA)
- Autogenous Periosteal Pedicle Graft Versus Pericardium Membrane in Management of Periodontal Intrabony Defects in Stage III Periodontitis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |