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normal saline - intravenous
normal saline - intravenous is a Crystalloid fluid / Electrolyte replacement Small molecule drug developed by Montefiore Medical Center. It is currently FDA-approved for Hypovolemia and dehydration, Perioperative fluid maintenance, Vehicle for intravenous medication administration.
Normal saline replaces fluid volume and electrolytes in the bloodstream to maintain hydration and osmotic balance.
Normal saline replaces fluid volume and electrolytes in the bloodstream to maintain hydration and osmotic balance. Used for Hypovolemia and dehydration, Perioperative fluid maintenance, Vehicle for intravenous medication administration.
At a glance
| Generic name | normal saline - intravenous |
|---|---|
| Sponsor | Montefiore Medical Center |
| Drug class | Crystalloid fluid / Electrolyte replacement |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Fluid Management |
| Phase | FDA-approved |
Mechanism of action
Normal saline (0.9% sodium chloride solution) is an isotonic crystalloid fluid that restores intravascular volume without causing fluid shifts between compartments. It provides essential sodium and chloride ions while the water component distributes across body fluid spaces. It is used for fluid resuscitation, maintenance hydration, and as a vehicle for medication delivery.
Approved indications
- Hypovolemia and dehydration
- Perioperative fluid maintenance
- Vehicle for intravenous medication administration
- Electrolyte replacement in sodium/chloride depletion
Common side effects
- Hyperchloremic acidosis
- Fluid overload / pulmonary edema
- Hypernatremia
- Phlebitis at infusion site
Key clinical trials
- Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC) (PHASE2, PHASE3)
- SMILE Trial - Imaging Sub-Study
- MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM) (PHASE3)
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade (PHASE2)
- Normal Saline Infusion After Intravenous Thrombolysis in Stroke (PHASE3)
- Pilot Study of IC14 (Atibuclimab), an Anti-CD14 Monoclonal Antibody, to Treat STEMI (PHASE1, PHASE2)
- Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- normal saline - intravenous CI brief — competitive landscape report
- normal saline - intravenous updates RSS · CI watch RSS
- Montefiore Medical Center portfolio CI
Frequently asked questions about normal saline - intravenous
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Related
- Drug class: All Crystalloid fluid / Electrolyte replacement drugs
- Manufacturer: Montefiore Medical Center — full pipeline
- Therapeutic area: All drugs in Critical Care / Fluid Management
- Indication: Drugs for Hypovolemia and dehydration
- Indication: Drugs for Perioperative fluid maintenance
- Indication: Drugs for Vehicle for intravenous medication administration
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing