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normal saline - injection
Normal saline is an isotonic crystalloid solution that replaces fluid and electrolytes lost through dehydration, bleeding, or other causes.
Normal saline is an isotonic crystalloid solution that replaces fluid and electrolytes lost through dehydration, bleeding, or other causes. Used for Fluid resuscitation and volume replacement in dehydration, Perioperative fluid management, Maintenance of vascular access and medication delivery.
At a glance
| Generic name | normal saline - injection |
|---|---|
| Sponsor | Montefiore Medical Center |
| Drug class | Crystalloid fluid / Electrolyte replacement solution |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Fluid & Electrolyte Management |
| Phase | FDA-approved |
Mechanism of action
Normal saline (0.9% sodium chloride in water) maintains osmotic balance with blood plasma, allowing safe intravenous administration without causing cell lysis or crenation. It restores intravascular volume and replaces sodium and chloride ions, making it a foundational fluid resuscitation agent used across acute care settings.
Approved indications
- Fluid resuscitation and volume replacement in dehydration
- Perioperative fluid management
- Maintenance of vascular access and medication delivery
- Electrolyte replacement in hyponatremia or hypochloremia
Common side effects
- Hyperchloremic acidosis
- Fluid overload / pulmonary edema
- Hypernatremia
- Phlebitis at infusion site
Key clinical trials
- PRP Injection Into the Sacroiliac Joint After Ipsilateral THA: Effects on Early Recovery and Function (SIJ-THA Randomized Trial) (NA)
- Endorotor Resection In Refractory Barrett's Dysplasia Patients (NA)
- Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC) (PHASE2, PHASE3)
- Tirzepatide in MetALD (PHASE2)
- FAP-targeted PET/NIR in Lung Malignant Tumors
- Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (PHASE2)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- SMILE Trial - Imaging Sub-Study
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- normal saline - injection CI brief — competitive landscape report
- normal saline - injection updates RSS · CI watch RSS
- Montefiore Medical Center portfolio CI