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Normal saline application
Normal saline is an isotonic sodium chloride solution that restores fluid balance and electrolyte homeostasis in the body.
Normal saline is an isotonic sodium chloride solution that restores fluid balance and electrolyte homeostasis in the body. Used for Fluid and electrolyte replacement in dehydration, Vehicle for intravenous drug administration, Wound irrigation and topical cleansing.
At a glance
| Generic name | Normal saline application |
|---|---|
| Sponsor | Keimyung University Dongsan Medical Center |
| Drug class | Electrolyte solution / Crystalloid fluid |
| Modality | Small molecule |
| Therapeutic area | General supportive care / Fluid and electrolyte management |
| Phase | FDA-approved |
Mechanism of action
Normal saline (0.9% NaCl) is a physiologic solution that matches the osmolarity of blood plasma, allowing safe intravenous or topical administration without causing cellular damage. It serves as a vehicle for drug delivery, maintains hydration status, and replaces lost fluids and electrolytes in various clinical settings. The solution has no active pharmacologic mechanism beyond fluid and electrolyte replacement.
Approved indications
- Fluid and electrolyte replacement in dehydration
- Vehicle for intravenous drug administration
- Wound irrigation and topical cleansing
- Maintenance of vascular access patency
Common side effects
- Hyperchloremic acidosis (with prolonged high-volume use)
- Fluid overload / pulmonary edema (in susceptible patients)
- Hypernatremia (rare, with excessive administration)
Key clinical trials
- Effect of Bladder Distension on Dosimetry in Brachytherapy of Cervical Cancer (NA)
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- The Development of New Functions of Esculin and Digitalis Glycosides Eye Drops: A Study on the Treatment of Presbyopia (PHASE4)
- EUSOL vs. PDGF Dressing for Diabetic Foot Ulcers (NA)
- Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation (NA)
- Comparison of Post-Operative Endodontic Pain Using Sodium Hypochlorite, Hydrogen Peroxide, and Normal Saline as Root Canal Irrigants (NA)
- Comparing Reduction With ESD- Versus APC-TORe (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |