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Normal bolus
Normal bolus is a standardized insulin injection protocol that rapidly delivers a concentrated dose of insulin to manage postprandial (after-meal) blood glucose spikes in diabetic patients.
Normal bolus is a standardized insulin injection protocol that rapidly delivers a concentrated dose of insulin to manage postprandial (after-meal) blood glucose spikes in diabetic patients. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus (when requiring insulin therapy), Acute hyperglycemia management.
At a glance
| Generic name | Normal bolus |
|---|---|
| Sponsor | University Hospital, Toulouse |
| Drug class | Insulin (rapid-acting or short-acting formulation) |
| Target | Insulin receptor |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Diabetes |
| Phase | FDA-approved |
Mechanism of action
A bolus is a single, rapid intravenous or subcutaneous injection of insulin designed to quickly lower elevated blood glucose levels, typically administered before meals or to correct hyperglycemia. Normal bolus refers to the conventional approach of using short-acting or rapid-acting insulin formulations to achieve prompt glycemic control. This contrasts with basal insulin therapy, which provides steady background insulin coverage.
Approved indications
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus (when requiring insulin therapy)
- Acute hyperglycemia management
Common side effects
- Hypoglycemia
- Weight gain
- Injection site reactions
- Lipodystrophy
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome (PHASE4)
- Neuronavigation-assisted Stereotactic Minimally Invasive Puncture With Tenecteplase for Acute Lobar Intracerebral Hemorrhage (PHASE3)
- Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery (NA)
- Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery (NA)
- The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies (PHASE3)
- Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours (PHASE3)
- Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |