Last reviewed · How we verify
Norepinephrine intravenous infusion
Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase blood pressure and heart rate.
Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase blood pressure and heart rate. Used for Acute hypotension and shock (septic shock, cardiogenic shock, anaphylactic shock), Maintenance of blood pressure during anesthesia.
At a glance
| Generic name | Norepinephrine intravenous infusion |
|---|---|
| Also known as | Noradrenaline, Levophed |
| Sponsor | University of Sao Paulo |
| Drug class | Catecholamine; sympathomimetic amine |
| Target | Alpha-1 adrenergic receptor; beta-1 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular; Critical Care |
| Phase | FDA-approved |
Mechanism of action
Norepinephrine acts as both a neurotransmitter and sympathomimetic agent, stimulating alpha-1 adrenergic receptors to cause vasoconstriction and increase peripheral vascular resistance, and beta-1 adrenergic receptors to increase cardiac contractility and heart rate. It is used intravenously to restore and maintain blood pressure in acute hypotensive states.
Approved indications
- Acute hypotension and shock (septic shock, cardiogenic shock, anaphylactic shock)
- Maintenance of blood pressure during anesthesia
Common side effects
- Hypertension
- Tachycardia
- Arrhythmias
- Headache
- Anxiety
- Tissue necrosis at infusion site
Key clinical trials
- Angiotensin II in Liver Transplantation (PHASE2, PHASE3)
- Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis (PHASE3)
- The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery (PHASE4)
- Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals. (NA)
- Comparison of Plasma Neutrophil Gelatinase-Associated Lipocalin (pNGAL) Level in De-resuscitation With Furosemide Group and Control Group (NA)
- Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor (PHASE4)
- Early Co-Administration of Crystalloid Fluid and Norepinephrine for Preventing Acute Kidney Injury in Septic Shock (NA)
- Early Vasopressors in Sepsis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Norepinephrine intravenous infusion CI brief — competitive landscape report
- Norepinephrine intravenous infusion updates RSS · CI watch RSS
- University of Sao Paulo portfolio CI