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Norepinephrine + Ascorbic Acid
Norepinephrine acts as a sympathomimetic agent to increase blood pressure and cardiac output, while ascorbic acid (vitamin C) may enhance catecholamine stability and provide antioxidant support.
Norepinephrine acts as a sympathomimetic agent to increase blood pressure and cardiac output, while ascorbic acid (vitamin C) may enhance stability and bioavailability of the norepinephrine formulation. Used for Acute hypotension and shock (septic, cardiogenic, or hypovolemic), Maintenance of blood pressure in critically ill patients.
At a glance
| Generic name | Norepinephrine + Ascorbic Acid |
|---|---|
| Sponsor | The University of Texas at Arlington |
| Drug class | Sympathomimetic amine / Vasopressor |
| Target | Alpha-1, alpha-2, and beta-1 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Critical Care |
| Phase | FDA-approved |
Mechanism of action
Norepinephrine binds to alpha and beta adrenergic receptors, causing vasoconstriction and increased heart rate and contractility to treat hypotension. Ascorbic acid is added to stabilize norepinephrine and prevent oxidative degradation, potentially improving drug efficacy and shelf-life. This combination is used primarily in acute care settings for hemodynamic support.
Approved indications
- Acute hypotension in critical care / intensive care settings
- Septic shock
- Cardiogenic shock
Common side effects
- Hypertension
- Tachycardia
- Arrhythmias
- Tissue necrosis at infusion site
- Anxiety / restlessness
Key clinical trials
- : Vascular Function in Health and Disease (PHASE1)
- Local Antioxidant Therapy Vasoconstriction Effects in Different Races (PHASE1)
- Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Norepinephrine + Ascorbic Acid CI brief — competitive landscape report
- Norepinephrine + Ascorbic Acid updates RSS · CI watch RSS
- The University of Texas at Arlington portfolio CI