Last reviewed 2026-04-23 · How we verify

NON-OPIOID

A non-opioid analgesic that works through mechanisms other than opioid receptor activation to reduce pain.

A non-opioid analgesic that works through mechanisms other than opioid receptor activation to reduce pain. Used for Chronic pain (indication pending specific drug identification), Acute pain (indication pending specific drug identification).

At a glance

Mechanism of action

Without a specific drug name or identifier, this represents a broad category of pain-relieving agents developed by Rutgers that do not act on opioid receptors. Non-opioid analgesics typically work through NSAIDs, acetaminophen-like mechanisms, or novel pain pathway modulation. The specific mechanism would depend on the particular compound in Phase 3 development.

Approved indications

• Chronic pain (indication pending specific drug identification)
• Acute pain (indication pending specific drug identification)

Common side effects

No common side effects on file.

Key clinical trials

• Opioid, HIV and Immune System (PHASE4)
• Management of Pain in Lumbar Arthrodesis (PHASE4)
• Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
• Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl
• NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty (NA)
• Dronabinol in Total Knee Arthroplasty (TKA) (PHASE4)
• Compared Reversed US-Guided Dorsal Penile Nerve Block (RUSDPNB) With DPNB in Circumcisions for Pediatric Patients (NA)
• Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3 (PHASE3)

Primary sources

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