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non-cross-linked hyaluronic acid
Non-cross-linked hyaluronic acid acts as a viscoelastic substance that lubricates, hydrates, and protects tissue surfaces through its hygroscopic and rheological properties.
Non-cross-linked hyaluronic acid acts as a viscoelastic substance that lubricates, hydrates, and protects tissue surfaces through its hygroscopic and rheological properties. Used for Osteoarthritis pain and joint lubrication, Ophthalmic surgery (anterior chamber maintenance), Wound healing and tissue repair.
At a glance
| Generic name | non-cross-linked hyaluronic acid |
|---|---|
| Also known as | physical therapy |
| Sponsor | Taipei Medical University |
| Drug class | Viscoelastic agent / Biopolymer |
| Modality | Small molecule |
| Therapeutic area | Orthopedics / Ophthalmology / Dermatology / Wound Care |
| Phase | FDA-approved |
Mechanism of action
Hyaluronic acid is a naturally occurring polysaccharide that binds water and creates a protective, lubricating layer on tissue surfaces. Non-cross-linked formulations are smaller molecular weight polymers that provide temporary hydration and cushioning effects without forming permanent chemical bonds. These properties make it useful for joint lubrication, wound healing, and mucosal protection.
Approved indications
- Osteoarthritis pain and joint lubrication
- Ophthalmic surgery (anterior chamber maintenance)
- Wound healing and tissue repair
Common side effects
- Injection site pain or swelling
- Temporary local inflammation
- Allergic reaction (rare)
Key clinical trials
- Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid (NA)
- Filler Post Market Survey (FIPS)
- A Study to Evaluate the Effectiveness and Safety of Restylane Skinboosters Vital Lidocaine (NA)
- Influence of Hyaluronic Acid in the Healing of Palatal Donor Sites During Free Gingival Graft Procedures (NA)
- Microneedling for Skin Heath (PHASE4)
- Randomized Masked Trial of Injectable Cross-Linked Hyaluronic Acid for Moderate-to-Severe Nasolabial Folds (NA)
- RHA® Redensity Eye Versus No-treatment for the Infra-Orbital Hollows (NA)
- The Correction of Midface Volume Deficiency and/or Midface Contour Deficiency (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- non-cross-linked hyaluronic acid CI brief — competitive landscape report
- non-cross-linked hyaluronic acid updates RSS · CI watch RSS
- Taipei Medical University portfolio CI