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Nitroglycerin patch
Nitroglycerin is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and dilate blood vessels.
Nitroglycerin is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and dilate blood vessels. Used for Angina pectoris (chronic stable angina), Acute coronary syndrome (acute angina relief).
At a glance
| Generic name | Nitroglycerin patch |
|---|---|
| Also known as | Nitro-Dur 0.1, Nitropaste, Rectocare - Ointment |
| Sponsor | GF Strong Rehabilitation Centre |
| Drug class | Nitrate vasodilator |
| Target | Soluble guanylate cyclase (via nitric oxide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Nitroglycerin is metabolized to nitric oxide, which activates guanylate cyclase and increases cyclic GMP levels in vascular smooth muscle cells. This leads to smooth muscle relaxation and vasodilation of both arteries and veins, reducing preload and afterload on the heart and improving coronary blood flow. The transdermal patch formulation provides sustained drug delivery over 24 hours.
Approved indications
- Angina pectoris (chronic stable angina)
- Acute coronary syndrome
- Heart failure (acute decompensated)
Common side effects
- Headache
- Dizziness
- Hypotension
- Tachycardia
- Contact dermatitis (at patch site)
- Tolerance (with continuous use)
Key clinical trials
- Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow (PHASE3)
- Subcutaneous Nitroglycerin to Facilitate Trans-radial Access. (PHASE4)
- Evaluating the Effects of Nitroglycerin on Heart Function and Urinary Output in Patients With Acute Heart Failure (PHASE4)
- Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy (NA)
- A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease (PHASE1)
- Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection (NA)
- Aerobic Exercise-induced Effect on Endothelial Function in Patients With Ischaemic Heart Disease (NA)
- Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nitroglycerin patch CI brief — competitive landscape report
- Nitroglycerin patch updates RSS · CI watch RSS
- GF Strong Rehabilitation Centre portfolio CI