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Neozepam (NITRAZEPAM)
Neozepam works by enhancing the activity of the neurotransmitter GABA, which helps to calm down overactive brain activity.
Neozepam, also known as nitrazepam, is a small molecule drug that targets the GABA-A receptor alpha-1/beta-2/gamma-2 subunits. It is a member of the benzodiazepine class and is used to treat insomnia and myoclonic seizures. The commercial status of Neozepam is unclear, and it is not FDA-approved. Neozepam has a half-life of 26 hours and a bioavailability of 78%. It is a potent anxiolytic and anticonvulsant agent.
At a glance
| Generic name | NITRAZEPAM |
|---|---|
| Drug class | nitrazepam |
| Target | GABA-A receptor alpha-1/beta-2/gamma-2 |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | discontinued |
Mechanism of action
Imagine your brain is like a busy city with lots of people talking and moving around. GABA is like a traffic cop that helps to slow down the traffic and keep everything calm. Neozepam helps the traffic cop to do its job more effectively, which can help to reduce anxiety and seizures.
Approved indications
- Insomnia
- Myoclonic seizure
Common side effects
- Enthesopathy
- Tenosynovitis
- Tongue disorder
- Tendonitis
- Blood parathyroid hormone decreased
- Panniculitis
- Granuloma skin
- Red blood cell sedimentation rate
- C-reactive protein abnormal
- Skin necrosis
- Rheumatoid nodule
- Alanine aminotransferase abnormal
Key clinical trials
- Music vs Midazolam During Preop Nerve Block Placement - Part 2 Study On Anxiolytic Options Before Peripheral Nerve Blocks (PHASE1,PHASE2)
- Music Therapy Model "The Bonny Method of Guided Imagery and Music" on Patients With Rheumatoid Arthritis (NA)
- A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease (PHASE2)
- Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE) (NA)
- SeRenade Parent-Child Music Class Program (NA)
- Pharmacovigilance in Gerontopsychiatric Patients (PHASE3)
- Safety and Efficacy of dRug-ElutiNg beADs Trans-arterial chemoEmbolization for Hepatocellular Carcinoma in Taiwan
- Ketogenic Diet in Infants With Epilepsy (KIWE) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Neozepam CI brief — competitive landscape report
- Neozepam updates RSS · CI watch RSS