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Nifedipine GITS (Adalat® XL 30
Nifedipine is a calcium channel blocker that inhibits calcium influx into vascular smooth muscle and cardiac cells, causing vasodilation and reduced blood pressure.
Nifedipine is a calcium channel blocker that inhibits calcium influx into vascular smooth muscle and cardiac cells, causing vasodilation and reduced blood pressure. Used for Hypertension, Angina pectoris.
At a glance
| Generic name | Nifedipine GITS (Adalat® XL 30 |
|---|---|
| Sponsor | Shanghai Jiao Tong University School of Medicine |
| Drug class | Calcium channel blocker (dihydropyridine) |
| Target | L-type calcium channel |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Nifedipine selectively blocks L-type calcium channels in the cell membrane, preventing calcium-dependent contraction of vascular smooth muscle. This leads to peripheral vasodilation, reduced systemic vascular resistance, and decreased blood pressure. The GITS (Gastrointestinal Therapeutic System) formulation provides extended-release delivery over 24 hours for once-daily dosing.
Approved indications
- Hypertension
- Angina pectoris
Common side effects
- Headache
- Flushing
- Peripheral edema
- Dizziness
- Palpitations
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