Last reviewed 2026-04-23 · How we verify

NH(3)

NH(3) (ammonia) is a nitrogen-containing compound that may modulate pulmonary hemodynamics and vascular function in cardiopulmonary disease.

NH(3) (ammonia) is a nitrogen-containing compound that may modulate pulmonary hemodynamics and vascular function in cardiopulmonary disease. Used for Pulmonary hypertension or related cardiopulmonary disease (specific indication not publicly confirmed).

At a glance

Mechanism of action

The exact mechanism is not well-established in public literature for this investigational designation. Ammonia and its derivatives have been studied for potential effects on nitric oxide metabolism and endothelial function in pulmonary hypertension and heart-lung disease contexts. Phase 3 development by NHLBI suggests evaluation in a serious cardiopulmonary indication, though the precise molecular target remains unclear.

Approved indications

• Pulmonary hypertension or related cardiopulmonary disease (specific indication not publicly confirmed)

Common side effects

No common side effects on file.

Key clinical trials

• Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies (PHASE4)
• A Study on the Safety, Reactogenicity and Immune Response of a Vaccine Against Influenza in Healthy Younger and Older Adults (PHASE1)
• 'Ai Pono Cooking Demonstrations (NA)
• Health Communications for Adults Smoking Nondaily (NA)
• 68Ga PSMA PET Imaging for the Treatment of Advanced Liver Cancer (PHASE2)
• Southwest Hub for American Indian Youth Suicide Prevention Research (NA)
• Natural Helpers and PCIT (NA)
• Effects of Exercise on Functional Ability in People With Dementia in Nursing Homes:a Cluster Randomised Controlled Trial (NA)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.