Last reviewed 2026-04-23 · How we verify

NER1006,1-Day Morning Split-Dosing

NER1006 is a bowel cleansing agent that works as an osmotic laxative to purge the colon of fecal matter in preparation for colonoscopy.

NER1006 is a bowel cleansing agent that works as an osmotic laxative to purge the colon of fecal matter in preparation for colonoscopy. Used for Bowel cleansing prior to colonoscopy.

At a glance

Mechanism of action

NER1006 is a polyethylene glycol (PEG)-based solution that draws water into the intestinal lumen through osmotic action, promoting bowel evacuation. The 1-day morning split-dosing regimen is designed to improve patient tolerability and compliance by reducing the total volume required and concentrating the dose into a shorter timeframe compared to traditional 2-day bowel preparation protocols.

Approved indications

• Bowel cleansing prior to colonoscopy

Common side effects

• Nausea
• Vomiting
• Abdominal pain
• Abdominal distension
• Dehydration

Key clinical trials

• Real Word Evidence With 1L Polyethylene Glycol (PEG)+ Ascorbic Acid in Iberia
• Colon Cleansing Efficacy With 1L vs. 2L vs. 4L-PEG for Colonoscopy Among Inpatients (PHASE4)
• Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults. (PHASE3)
• Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults. (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.