Last reviewed · How we verify
Nebulized beclomethasone dipropionate
Beclomethasone dipropionate is a corticosteroid that suppresses airway inflammation by binding to glucocorticoid receptors and reducing inflammatory mediator production.
Beclomethasone dipropionate is a corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors and suppressing inflammatory mediator release. Used for Asthma maintenance therapy, Chronic obstructive pulmonary disease (COPD).
At a glance
| Generic name | Nebulized beclomethasone dipropionate |
|---|---|
| Also known as | BDP |
| Sponsor | Istituto per la Ricerca e l'Innovazione Biomedica |
| Drug class | Inhaled corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Mechanism of action
When nebulized and inhaled, beclomethasone dipropionate is converted to its active metabolite and penetrates airway tissues where it binds intracellular glucocorticoid receptors. This activation suppresses the transcription of pro-inflammatory cytokines, chemokines, and adhesion molecules, reducing eosinophil recruitment, mucus production, and airway hyperresponsiveness. The local delivery via nebulization minimizes systemic exposure while maximizing therapeutic effect in the lungs.
Approved indications
- Asthma (maintenance and reliever therapy)
- Chronic obstructive pulmonary disease (COPD)
Common side effects
- Oropharyngeal candidiasis
- Dysphonia / hoarseness
- Tremor
- Headache
- Throat irritation
Key clinical trials
- Comparison of 3% Normal Saline Nebulization Versus Steroid Nebulization in the Treatment of Bronchiolitis (EARLY_PHASE1)
- Efficacy of Nebulized Lidocaine, Salbutamol, and Beclomethasone Plus Salbutamol in the Covid-19 Patients With ARDS on Non-invasive Ventilation; Randomized Control Trial (PHASE1)
- Inhaled Steroids for Pediatric Asthma at Pediatric Emergency Medicine Discharge (PHASE4)
- Nebulized Beclometasone Dipropionate Improves Nasal Patency in Children With Allergic Rhinitis (PHASE4)
- Nebulized Beclomethasone Dipropionate Improves Respiratory Lung Function in Preschool Children With Recurrent Wheezing (PHASE4)
- Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup (PHASE3)
- Assessment of Oxidative Stress Markers in the Upper and Lower Airways of Atopic Children Treated With Nebulized Beclomethasone (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: