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NCCN Chemotherapy
NCCN Chemotherapy refers to a standardized chemotherapy regimen recommended by the National Comprehensive Cancer Network, typically combining multiple cytotoxic agents to inhibit cancer cell division and induce apoptosis.
NCCN Chemotherapy refers to a standardized chemotherapy regimen recommended by the National Comprehensive Cancer Network, typically combining multiple cytotoxic agents to inhibit cancer cell division and induce apoptosis. Used for Various solid tumors and hematologic malignancies (indication-specific per NCCN guidelines).
At a glance
| Generic name | NCCN Chemotherapy |
|---|---|
| Also known as | Chemotherapy strategy for controlled group |
| Sponsor | Sun Yat-sen University |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
NCCN chemotherapy protocols are evidence-based treatment guidelines that combine chemotherapeutic drugs with complementary mechanisms of action to maximize tumor cell kill while managing toxicity. These regimens are tailored to specific cancer types and stages, often including agents that target DNA synthesis, microtubule stability, or other critical cellular processes. The specific drugs and dosing vary by indication and patient factors.
Approved indications
- Various solid tumors and hematologic malignancies (indication-specific per NCCN guidelines)
Common side effects
- Myelosuppression (neutropenia, anemia, thrombocytopenia)
- Nausea and vomiting
- Mucositis
- Alopecia
- Fatigue
- Peripheral neuropathy
Key clinical trials
- Phase III, Multicenter, Randomized Controlled Clinical Study of Three-Dimensional Radiotherapy for Primary Tumors in Non-Oligometastatic Stage IV Non-Small Cell Lung Cancer (NA)
- Remote Monitoring and Management of Chemotherapy Induced Peripheral Neuropathy (NA)
- A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC) (PHASE2)
- Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy (PHASE2)
- Neoadjuvant CAPEOX Versus Upfront Surgery for Locally Advanced Colon Cancer With Elevated CEA: A Single-Center, Open-Label, Randomized Controlled Trial (NA)
- Daily Adaptive Radiation Therapy: An Individualized Approach for Stage III Lung Cancer (NA)
- Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma (NA)
- A Prospective, Safety, and Efficacy Clinical Trial of Pressurized Intraperitoneal Aerosol Therapy for Peritoneal Metastasis of Colorectal Cancer (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |