Last reviewed · How we verify
Nasal Fluticasone
Nasal Fluticasone is a Intranasal corticosteroid Small molecule drug developed by Children's Hospital of Philadelphia. It is currently FDA-approved for Allergic rhinitis, Nasal polyps, Chronic rhinosinusitis. Also known as: NCS, Nasal steroids, Nasal corticosteroids.
Fluticasone is a corticosteroid that reduces inflammation in the nasal passages by suppressing immune cell activity and inflammatory mediator release.
Nasal Fluticasone is a small molecule glucocorticoid receptor agonist used to treat various conditions, including perennial and seasonal allergic rhinitis, and allergic rhinitis. It is administered as a nasal spray and belongs to the drug class of glucocorticoid receptor agonists.
At a glance
| Generic name | Nasal Fluticasone |
|---|---|
| Also known as | NCS, Nasal steroids, Nasal corticosteroids |
| Sponsor | Children's Hospital of Philadelphia |
| Drug class | Intranasal corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Allergy/Immunology |
| Phase | FDA-approved |
Mechanism of action
Fluticasone propionate binds to glucocorticoid receptors in nasal tissue, inhibiting the production of pro-inflammatory cytokines and chemokines. This reduces swelling, mucus production, and allergic/inflammatory responses in the nasal cavity. When administered as a nasal spray, it provides local anti-inflammatory effects with minimal systemic absorption.
Approved indications
- Allergic rhinitis
- Nasal polyps
- Chronic rhinosinusitis
Common side effects
- Epistaxis (nosebleed)
- Nasal irritation
- Headache
- Pharyngitis
- Cough
Key clinical trials
- Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps (PHASE3)
- Effect of Novel Exhalational Delivery System With Fluticasone (EDS-FLU) on Eustachian Tube Dysfunction (ETD) (PHASE2)
- INTRANASAL FLUTICASONE VERSUS FLUTICASONE-AZELASTINE COMBINATION (PHASE4)
- A Prospective, Randomized, Controlled Study Comparing the Efficacy of Intranasal Corticosteroids (INCS) Combined With Intranasal Antihistamines (INAH) and INCS Combined With Oral Antihistamines (OAH) in the Treatment of Moderate to Severe Allergic Rhinitis Symptoms (PHASE4)
- As Needed Versus Regular Intranasal Corticosteroid in Children With Perennial Allergic Rhinitis (PHASE3)
- Vibroacoustic Therapy With Oscillating Positive Expiratory Pressure in the Treatment of Nasal Congestion (NA)
- Budesonide Nasal Irrigation Versus Fluticasone Propionate Nasal Spray in Treating Allergic Rhinitis Patients (PHASE4)
- Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nasal Fluticasone CI brief — competitive landscape report
- Nasal Fluticasone updates RSS · CI watch RSS
- Children's Hospital of Philadelphia portfolio CI
Frequently asked questions about Nasal Fluticasone
What is Nasal Fluticasone?
How does Nasal Fluticasone work?
What is Nasal Fluticasone used for?
Who makes Nasal Fluticasone?
Is Nasal Fluticasone also known as anything else?
What drug class is Nasal Fluticasone in?
What development phase is Nasal Fluticasone in?
What are the side effects of Nasal Fluticasone?
What does Nasal Fluticasone target?
Related
- Drug class: All Intranasal corticosteroid drugs
- Target: All drugs targeting Glucocorticoid receptor
- Manufacturer: Children's Hospital of Philadelphia — full pipeline
- Therapeutic area: All drugs in Allergy/Immunology
- Indication: Drugs for Allergic rhinitis
- Indication: Drugs for Nasal polyps
- Indication: Drugs for Chronic rhinosinusitis
- Also known as: NCS, Nasal steroids, Nasal corticosteroids
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing