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Narcotic Analgesics
Narcotic analgesics work by binding to opioid receptors in the brain, spinal cord, and other areas, altering the perception of and response to pain.
Narcotic analgesics work by binding to opioid receptors in the brain, spinal cord, and other areas, altering the perception of and response to pain. Used for Management of moderate to severe pain, Cancer pain.
At a glance
| Generic name | Narcotic Analgesics |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Narcotic analgesic |
| Target | Opioid receptors (mu, delta, kappa) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
This binding causes a decrease in the release of pain-producing neurotransmitters, such as substance P, and an increase in the release of pain-reducing neurotransmitters, such as endorphins. As a result, narcotic analgesics can provide effective pain relief, but they also carry a risk of dependence and addiction.
Approved indications
- Management of moderate to severe pain
- Cancer pain
Common side effects
- Nausea
- Vomiting
- Constipation
- Dizziness
- Drowsiness
Key clinical trials
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases (PHASE2)
- Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction (PHASE2, PHASE3)
- Ear Pressure Points Plus Pain Meds for Faster Kidney Stone Pain Relief (NA)
- Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population (PHASE2)
- No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair (PHASE4)
- Association of Erectile Dysfunction With Neuropathic Pain, Disease Activity, and Functional Status in Male Patients With Axial Spondyloarthritis: A Cross-Sectional Observational Study
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Narcotic Analgesics CI brief — competitive landscape report
- Narcotic Analgesics updates RSS · CI watch RSS
- Ain Shams University portfolio CI