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NaHCO3
Sodium bicarbonate acts as a systemic alkalizing agent that neutralizes excess acid in the body.
Sodium bicarbonate acts as a systemic alkalizing agent that neutralizes excess acid in the body. Used for Metabolic acidosis, Gastric acid indigestion / heartburn, Urine alkalinization for drug overdose management.
At a glance
| Generic name | NaHCO3 |
|---|---|
| Also known as | Sodium Bicarbonate |
| Sponsor | Karadeniz Technical University |
| Drug class | Antacid / Alkalizing agent |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Nephrology / General Medicine |
| Phase | FDA-approved |
Mechanism of action
NaHCO3 dissociates to provide bicarbonate ions that buffer hydrogen ions and increase blood pH. It is used to treat metabolic acidosis, alkalinize urine for certain drug overdoses or kidney stone prevention, and provide symptomatic relief of acid indigestion. The bicarbonate ion directly neutralizes gastric acid and systemic acidosis.
Approved indications
- Metabolic acidosis
- Gastric acid indigestion and heartburn
- Urine alkalinization for drug overdose management
- Kidney stone prevention
Common side effects
- Metabolic alkalosis
- Hypokalemia
- Nausea
- Flatulence / Gas
- Headache
Key clinical trials
- Two Intermediate Expanded Access Protocols (EAP) CNMAu8.EAP01 and CNMAu8.EAP02 for ALS
- SODium BICarbonate for Metabolic Acidosis in the ICU (PHASE3)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Efficacy of High-Level Laser Therapy in Managing Oral Mucositis Among Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation (NA)
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates (NA)
- Prevention of Oral Mucositis in Head and Neck Cancer. (NA)
- Alginate vs Sucralfate for GERD Symptomatic Relief (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- NaHCO3 CI brief — competitive landscape report
- NaHCO3 updates RSS · CI watch RSS
- Karadeniz Technical University portfolio CI