sodium Fluoride Varnish

Nisreen Ibrahim khan · FDA-approved active Small molecule

sodium Fluoride Varnish is a Topical fluoride agent Small molecule drug developed by Nisreen Ibrahim khan. It is currently FDA-approved for Dental caries prevention in children and adults, Enamel remineralization and desensitization, High-risk caries patients. Also known as: NaF, VOCO profluorid varnish, 2.26% F, Duraphat, WoelmPharma GmbH, Germany, Duraphat (Colgate).

Sodium fluoride varnish strengthens tooth enamel and dentin by promoting remineralization and inhibiting bacterial acid production.

Sodium fluoride varnish strengthens tooth enamel and dentin by promoting remineralization and inhibiting bacterial acid production. Used for Dental caries prevention in children and adults, Enamel remineralization and desensitization, High-risk caries patients.

At a glance

Generic name	sodium Fluoride Varnish
Also known as	NaF, VOCO profluorid varnish, 2.26% F, Duraphat, WoelmPharma GmbH, Germany, Duraphat (Colgate), ClinproTM White Varnish
Sponsor	Nisreen Ibrahim khan
Drug class	Topical fluoride agent
Target	Hydroxyapatite in tooth enamel and dentin; bacterial glycolytic enzymes
Modality	Small molecule
Therapeutic area	Dentistry / Preventive Oral Health
Phase	FDA-approved

Mechanism of action

Fluoride ions penetrate the tooth structure and replace hydroxyl groups in hydroxyapatite, forming fluorapatite, which is more resistant to acid demineralization. The varnish formulation provides prolonged contact time with tooth surfaces, enhancing fluoride uptake. Additionally, fluoride inhibits glycolysis in cariogenic bacteria, reducing their ability to produce acids that cause dental decay.

Approved indications

• Dental caries prevention in children and adults
• Enamel remineralization and desensitization
• High-risk caries patients

Common side effects

• Dental fluorosis (mild, cosmetic)
• Temporary tooth staining or discoloration
• Mild gingival irritation
• Nausea or gastrointestinal upset (if ingested)

Key clinical trials

• Preventing Early Childhood Caries With a Silver Diamine Fluoride Gel (PHASE2)
• Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity (NA)
• Traditional vs. Minimally Invasive Decay Treatments in Primary Molars: An 18-month Split-mouth Randomized Study (NA)
• Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary Teeth: A Randomized Clinical Trial (NA)
• Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious Lesions (NA)
• Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children (NA)
• Effect Of Silverdiamine Fluoride Gel, Sodium Fluoride With CPP-ACP, APF On Early Childhood Caries - A Randomised Controlled Trial (PHASE2)
• Minimally Invasive Protocols for the Treatment and Control of Caries Lesions in Children and Adolescents (NA)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• sodium Fluoride Varnish CI brief — competitive landscape report
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• Nisreen Ibrahim khan portfolio CI

Frequently asked questions about sodium Fluoride Varnish

What is sodium Fluoride Varnish?

sodium Fluoride Varnish is a Topical fluoride agent drug developed by Nisreen Ibrahim khan, indicated for Dental caries prevention in children and adults, Enamel remineralization and desensitization, High-risk caries patients.

How does sodium Fluoride Varnish work?

Sodium fluoride varnish strengthens tooth enamel and dentin by promoting remineralization and inhibiting bacterial acid production.

What is sodium Fluoride Varnish used for?

sodium Fluoride Varnish is indicated for Dental caries prevention in children and adults, Enamel remineralization and desensitization, High-risk caries patients.

Who makes sodium Fluoride Varnish?

sodium Fluoride Varnish is developed and marketed by Nisreen Ibrahim khan (see full Nisreen Ibrahim khan pipeline at /company/nisreen-ibrahim-khan).

Is sodium Fluoride Varnish also known as anything else?

sodium Fluoride Varnish is also known as NaF, VOCO profluorid varnish, 2.26% F, Duraphat, WoelmPharma GmbH, Germany, Duraphat (Colgate), ClinproTM White Varnish.

What drug class is sodium Fluoride Varnish in?

sodium Fluoride Varnish belongs to the Topical fluoride agent class. See all Topical fluoride agent drugs at /class/topical-fluoride-agent.

What development phase is sodium Fluoride Varnish in?

sodium Fluoride Varnish is FDA-approved (marketed).

What are the side effects of sodium Fluoride Varnish?

Common side effects of sodium Fluoride Varnish include Dental fluorosis (mild, cosmetic), Temporary tooth staining or discoloration, Mild gingival irritation, Nausea or gastrointestinal upset (if ingested).

What does sodium Fluoride Varnish target?

sodium Fluoride Varnish targets Hydroxyapatite in tooth enamel and dentin; bacterial glycolytic enzymes and is a Topical fluoride agent.

Related

• Drug class: All Topical fluoride agent drugs
• Target: All drugs targeting Hydroxyapatite in tooth enamel and dentin; bacterial glycolytic enzymes
• Manufacturer: Nisreen Ibrahim khan — full pipeline
• Therapeutic area: All drugs in Dentistry / Preventive Oral Health
• Indication: Drugs for Dental caries prevention in children and adults
• Indication: Drugs for Enamel remineralization and desensitization
• Indication: Drugs for High-risk caries patients
• Also known as: NaF, VOCO profluorid varnish, 2.26% F, Duraphat, WoelmPharma GmbH, Germany, Duraphat (Colgate), ClinproTM White Varnish