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N-butyl-2-cyanoacrylate

West China Hospital · Phase 3 active Small molecule

N-butyl-2-cyanoacrylate is a Tissue adhesive / Hemostatic agent Small molecule drug developed by West China Hospital. It is currently in Phase 3 development for Hemostasis and tissue sealing in endovascular procedures, Embolization of vascular malformations and bleeding vessels, Endoscopic hemostasis for gastrointestinal bleeding.

N-butyl-2-cyanoacrylate is a tissue adhesive that polymerizes rapidly upon contact with moisture to form a strong bond, used for hemostasis and tissue sealing in endovascular and surgical applications.

N-butyl-2-cyanoacrylate is a tissue adhesive that polymerizes rapidly upon contact with moisture to form a strong bond, used for hemostasis and tissue sealing in endovascular and surgical applications. Used for Hemostasis and tissue sealing in endovascular procedures, Embolization of vascular malformations and bleeding vessels, Endoscopic hemostasis for gastrointestinal bleeding.

At a glance

Generic nameN-butyl-2-cyanoacrylate
SponsorWest China Hospital
Drug classTissue adhesive / Hemostatic agent
ModalitySmall molecule
Therapeutic areaSurgery / Interventional Radiology / Hemostasis
PhasePhase 3

Mechanism of action

This cyanoacrylate monomer undergoes anionic polymerization when exposed to water or blood, creating a solid polymer that adheres to tissue surfaces and seals vessels or defects. It is commonly used in interventional radiology and endoscopy for embolization, hemostasis, and closure of vascular malformations or bleeding sites. The rapid polymerization and strong adhesive properties make it effective for minimally invasive hemostatic control.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about N-butyl-2-cyanoacrylate

What is N-butyl-2-cyanoacrylate?

N-butyl-2-cyanoacrylate is a Tissue adhesive / Hemostatic agent drug developed by West China Hospital, indicated for Hemostasis and tissue sealing in endovascular procedures, Embolization of vascular malformations and bleeding vessels, Endoscopic hemostasis for gastrointestinal bleeding.

How does N-butyl-2-cyanoacrylate work?

N-butyl-2-cyanoacrylate is a tissue adhesive that polymerizes rapidly upon contact with moisture to form a strong bond, used for hemostasis and tissue sealing in endovascular and surgical applications.

What is N-butyl-2-cyanoacrylate used for?

N-butyl-2-cyanoacrylate is indicated for Hemostasis and tissue sealing in endovascular procedures, Embolization of vascular malformations and bleeding vessels, Endoscopic hemostasis for gastrointestinal bleeding.

Who makes N-butyl-2-cyanoacrylate?

N-butyl-2-cyanoacrylate is developed by West China Hospital (see full West China Hospital pipeline at /company/west-china-hospital).

What drug class is N-butyl-2-cyanoacrylate in?

N-butyl-2-cyanoacrylate belongs to the Tissue adhesive / Hemostatic agent class. See all Tissue adhesive / Hemostatic agent drugs at /class/tissue-adhesive-hemostatic-agent.

What development phase is N-butyl-2-cyanoacrylate in?

N-butyl-2-cyanoacrylate is in Phase 3.

What are the side effects of N-butyl-2-cyanoacrylate?

Common side effects of N-butyl-2-cyanoacrylate include Vessel occlusion or thrombosis, Tissue necrosis or inflammation, Allergic or foreign body reaction, Unintended polymerization or catheter adhesion.

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