Last reviewed 2026-04-23 · How we verify

mupirocin 2% ointment

Mupirocin 2% ointment works by inhibiting bacterial protein synthesis, specifically targeting isoleucyl-tRNA synthetase.

Mupirocin 2% ointment works by inhibiting bacterial protein synthesis, specifically targeting isoleucyl-tRNA synthetase. Used for Treatment of impetigo, secondarily infected eczema, and minor cuts and scrapes.

At a glance

Mechanism of action

This inhibition prevents the bacteria from producing essential proteins, ultimately leading to cell death. Mupirocin is a potent inhibitor of bacterial growth, particularly effective against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes.

Approved indications

• Treatment of impetigo, secondarily infected eczema, and minor cuts and scrapes

Common side effects

• Skin burning sensation
• Skin irritation

Key clinical trials

• Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients (PHASE4)
• Staph Household Intervention for Eradication (SHINE) (PHASE4)
• STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) (PHASE2)
• Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO) (PHASE2)
• Bacterial Decolonization Within Dyads (NA)
• The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal (PHASE3)
• Decolonization to Reduce After-Surgery Events of Surgical Site Infection (PHASE4)
• Surgical Wound Infection Prevention Bundle in Patients Undergoing Coronary Bypass Graft Surgery (NA)

Primary sources

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