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Mineral trioxide aggregate
Mineral trioxide aggregate is a Small molecule drug developed by Universidad de los Andes, Chile. It is currently FDA-approved for Root canal obturation and sealing, Perforation repair in endodontic treatment, Apexification in immature teeth. Also known as: MTA Pro Root, MTA pulpotomy, MTA, (ProRoot MTA).
Mineral trioxide aggregate (MTA) is a biocompatible cement that sets through a hydration reaction, creating a hard matrix that seals and promotes healing in endodontic and dental applications.
Mineral trioxide aggregate (MTA) is a biocompatible cement that sets through a hydration reaction, creating a hard matrix that seals and promotes healing in dental and endodontic applications. Used for Pulp capping and pulpotomy in vital teeth, Apical barrier formation in immature permanent teeth with open apices, Repair of root perforations.
At a glance
| Generic name | Mineral trioxide aggregate |
|---|---|
| Also known as | MTA Pro Root, MTA pulpotomy, MTA, (ProRoot MTA) |
| Sponsor | Universidad de los Andes, Chile |
| Modality | Small molecule |
| Therapeutic area | Dentistry/Endodontics |
| Phase | FDA-approved |
Mechanism of action
MTA consists of Portland cement and bismuth oxide, which hydrate to form calcium silicate hydrate and calcium hydroxide. These products create a biocompatible, antimicrobial barrier that promotes periapical healing and hard tissue formation. It is used primarily in endodontics for root canal treatment, perforation repair, and apexification.
Approved indications
- Root canal obturation and sealing
- Perforation repair in endodontic treatment
- Apexification in immature teeth
- Pulp capping and pulpotomy
Common side effects
- Discoloration of tooth structure
- Difficulty in removal if over-extended
- Allergic reaction (rare)
Key clinical trials
- Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy in Mature Permanent Molars With Irreversible Pulpitis (NA)
- Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions (NA)
- Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis (NA)
- Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth (NA)
- Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth (PHASE4)
- Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions (NA)
- Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth (PHASE3)
- Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mineral trioxide aggregate CI brief — competitive landscape report
- Mineral trioxide aggregate updates RSS · CI watch RSS
- Universidad de los Andes, Chile portfolio CI
Frequently asked questions about Mineral trioxide aggregate
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Related
- Manufacturer: Universidad de los Andes, Chile — full pipeline
- Therapeutic area: All drugs in Dentistry/Endodontics
- Indication: Drugs for Root canal obturation and sealing
- Indication: Drugs for Perforation repair in endodontic treatment
- Indication: Drugs for Apexification in immature teeth
- Also known as: MTA Pro Root, MTA pulpotomy, MTA, (ProRoot MTA)